• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

优化提取的银杏叶提取物761：在将细胞色素P450酶干扰降至最低的同时增强治疗效果。

Optimized extract EGb 761: boosted therapeutic benefits with minimized CYP enzyme interference.

作者信息

Kwon Sunbeom, Jeong Suji, Lee Seulah

机构信息

Department of Convergent Biotechnology and Advanced Materials Science, College of Life Sciences, Kyung Hee University, Yongin, Republic of Korea.

BK21 Interdisciplinary Program in IT-Bio Convergence System, Kyung Hee University, Yongin, Republic of Korea.

出版信息

J Pharm Pharm Sci. 2025 Aug 26;28:14614. doi: 10.3389/jpps.2025.14614. eCollection 2025.

DOI:10.3389/jpps.2025.14614
PMID:40933618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12417213/
Abstract

OBJECT

The development of cognitive-enhancing drugs from extract is actively pursued worldwide. This study compares the chemical compositions of different extracts and their formulated drugs, highlighting the distinguishing characteristics and potential benefits of optimized extract, EGb 761.

METHODS

We analyzed three extracts and fifteen formulated drugs using HPLC, principal component analysis, and LC-MS/MS to identify key compositional differences. Molecular docking analysis was conducted to evaluate the binding affinity of the key component with a target protein involved in cognitive enhancement. CYP inhibition assays were performed on selected extracts and their derived products to examine drug-drug interactions.

RESULTS

EGb 761 and its formulated drugs displayed a unique composition, characterized by a significantly higher level of protocatechuic acid (PCA). PCA demonstrated strong interactions with the M receptor, acetylcholinesterase, glycogen synthase kinase-3, which are the key targets for cognitive enhancement. CYP inhibition assays indicated that EGb 761 and the drugs derived from EGb 761 had lower inhibitory activity compared to other samples.

CONCLUSION

The high PCA content in EGb 761 may contribute to cognitive benefits. With low CYP inhibition, it suggests minimal interference with drug metabolism, highlighting its potential as a safer cognitive enhancer. Ultimately, this study indicates that the composition of EGb 761 can be effectively leveraged for its pharmacological benefits.

摘要

目的

全球都在积极致力于从提取物中开发认知增强药物。本研究比较了不同提取物及其制成药物的化学成分，突出了优化提取物EGb 761的显著特征和潜在益处。

方法

我们使用高效液相色谱法（HPLC）、主成分分析和液相色谱-质谱/质谱联用技术（LC-MS/MS）分析了三种提取物和十五种制成药物，以确定关键的成分差异。进行分子对接分析以评估关键成分与参与认知增强的靶蛋白的结合亲和力。对选定的提取物及其衍生产品进行细胞色素P450（CYP）抑制试验，以检查药物相互作用。

结果

EGb 761及其制成药物呈现出独特的成分，其特征是原儿茶酸（PCA）水平显著更高。PCA与M受体、乙酰胆碱酯酶、糖原合酶激酶-3表现出强烈相互作用，这些都是认知增强的关键靶点。CYP抑制试验表明，与其他样品相比，EGb 761及其衍生药物的抑制活性较低。

结论

EGb 761中高含量的PCA可能有助于认知益处。由于其CYP抑制作用较低，这表明对药物代谢的干扰最小，突出了其作为更安全的认知增强剂的潜力。最终，本研究表明EGb 761的成分可有效地用于其药理学益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/801e46b56a01/jpps-28-14614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/59312bd0119b/jpps-28-14614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/9ad82faafb9c/jpps-28-14614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/57c905e98e9b/jpps-28-14614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/76c243bbd63e/jpps-28-14614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/dc1ae04405f5/jpps-28-14614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/e9c9ae57f0ed/jpps-28-14614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/ada6238d6e4f/jpps-28-14614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/801e46b56a01/jpps-28-14614-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/59312bd0119b/jpps-28-14614-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/9ad82faafb9c/jpps-28-14614-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/57c905e98e9b/jpps-28-14614-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/76c243bbd63e/jpps-28-14614-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/dc1ae04405f5/jpps-28-14614-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/e9c9ae57f0ed/jpps-28-14614-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/ada6238d6e4f/jpps-28-14614-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e237/12417213/801e46b56a01/jpps-28-14614-g008.jpg

相似文献

1
Optimized extract EGb 761: boosted therapeutic benefits with minimized CYP enzyme interference.优化提取的银杏叶提取物761：在将细胞色素P450酶干扰降至最低的同时增强治疗效果。
J Pharm Pharm Sci. 2025 Aug 26;28:14614. doi: 10.3389/jpps.2025.14614. eCollection 2025.
2
Prescription of Controlled Substances: Benefits and Risks管制药品的处方：益处与风险
3
Ginkgo biloba for cognitive impairment and dementia.银杏叶用于认知障碍和痴呆症。
Cochrane Database Syst Rev. 2002(4):CD003120. doi: 10.1002/14651858.CD003120.
4
Neuroprotective effect and possible mechanisms of the extract of ginkgo biloba for spinal cord injury in experimental animal: a meta-analysis and systematic review.银杏叶提取物对实验动物脊髓损伤的神经保护作用及可能机制：一项Meta分析和系统评价
Nutr Neurosci. 2025 Jul;28(7):840-853. doi: 10.1080/1028415X.2024.2425643. Epub 2025 Feb 28.
5
Ginkgo biloba for cognitive impairment and dementia.银杏叶治疗认知障碍和痴呆症。
Cochrane Database Syst Rev. 2009 Jan 21(1):CD003120. doi: 10.1002/14651858.CD003120.pub3.
6
Ginkgo biloba for cognitive impairment and dementia.银杏叶用于认知障碍和痴呆症。
Cochrane Database Syst Rev. 2007 Apr 18(2):CD003120. doi: 10.1002/14651858.CD003120.pub2.
7
Ginkgo biloba extract for age-related macular degeneration.用于年龄相关性黄斑变性的银杏叶提取物。
Cochrane Database Syst Rev. 2013 Jan 31;2013(1):CD001775. doi: 10.1002/14651858.CD001775.pub2.
8
Ginkgo biloba for tinnitus.银杏叶治疗耳鸣。
Cochrane Database Syst Rev. 2022 Nov 16;11(11):CD013514. doi: 10.1002/14651858.CD013514.pub2.
9
Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment.银杏叶提取物50对认知障碍的保护作用中线粒体氧化应激和细胞凋亡的抑制
J Ethnopharmacol. 2025 Jul 24;351:120059. doi: 10.1016/j.jep.2025.120059. Epub 2025 May 29.
10
Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials.银杏叶提取物EGb 761®治疗痴呆症的疗效和耐受性：随机安慰剂对照试验的系统评价和荟萃分析
Clin Interv Aging. 2014 Nov 28;9:2065-77. doi: 10.2147/CIA.S72728. eCollection 2014.

本文引用的文献

1
Pharmacological Postconditioning by Protocatechuic Acid Attenuates Brain Injury in Ischemia-Reperfusion (I/R) Mice Model: Implications of Nuclear Factor Erythroid-2-Related Factor Pathway.原儿茶酸的药物性后处理减轻脑缺血再灌注（I/R）模型小鼠的脑损伤：核因子红细胞 2 相关因子通路的作用。
Neuroscience. 2022 May 21;491:23-31. doi: 10.1016/j.neuroscience.2022.03.016. Epub 2022 Mar 18.
2
Prevalence of Dementia in Korea Based on Hospital Utilization Data from 2008 to 2016.基于2008年至2016年医院利用数据的韩国痴呆症患病率
Yonsei Med J. 2021 Oct;62(10):948-953. doi: 10.3349/ymj.2021.62.10.948.
3
Advances in the chemical constituents and chemical analysis of Ginkgo biloba leaf, extract, and phytopharmaceuticals.
银杏叶、提取物和植物药的化学成分及化学分析研究进展。
J Pharm Biomed Anal. 2021 Jan 30;193:113704. doi: 10.1016/j.jpba.2020.113704. Epub 2020 Oct 25.
4
Synergistic Effects of Ginkgolide B and Protocatechuic Acid on the Treatment of Parkinson's Disease.银杏内酯 B 和原儿茶酸在治疗帕金森病方面的协同作用。
Molecules. 2020 Aug 31;25(17):3976. doi: 10.3390/molecules25173976.
5
Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model.原儿茶酸对淀粉样β诱导阿尔茨海默病模型小鼠认知障碍的保护作用。
Food Chem Toxicol. 2020 Oct;144:111571. doi: 10.1016/j.fct.2020.111571. Epub 2020 Jul 15.
6
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders.抑郁和其他脑部疾病中 GABA 介导的信息处理改变和认知功能障碍。
Mol Psychiatry. 2021 Jan;26(1):151-167. doi: 10.1038/s41380-020-0727-3. Epub 2020 Apr 28.
7
Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment.原儿茶酸给药可改善 D-半乳糖诱导的记忆障碍大鼠模型的记忆能力，并恢复海马和皮质中的 5-羟色胺代谢。
Behav Brain Res. 2019 Aug 5;368:111896. doi: 10.1016/j.bbr.2019.04.010. Epub 2019 Apr 9.
8
Molecular Docking and Cognitive Impairment Attenuating Effect of Phenolic Compound Rich Fraction of Trianthema portulacastrum in Scopolamine Induced Alzheimer's Disease Like Condition.三疣棱子蟹酚类化合物富分组分的分子对接及对东莨菪碱诱导的阿尔茨海默病样条件下认知障碍的影响。
Neurochem Res. 2019 Jul;44(7):1665-1677. doi: 10.1007/s11064-019-02792-7. Epub 2019 Apr 4.
9
Protocatechuic acid ameliorates neurocognitive functions impairment induced by chronic intermittent hypoxia.原儿茶酸改善慢性间歇性缺氧诱导的神经认知功能损害。
Sci Rep. 2015 Sep 30;5:14507. doi: 10.1038/srep14507.
10
Cognitive enhancement.认知增强。
Wiley Interdiscip Rev Cogn Sci. 2014 Jan;5(1):95-103. doi: 10.1002/wcs.1250. Epub 2013 Oct 22.