Chang Junjie, Zhang Wenjun, Wang Hua, Song Xin, Yu Dan
Department of Medical Ultrasound, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Front Oncol. 2025 Aug 26;15:1587411. doi: 10.3389/fonc.2025.1587411. eCollection 2025.
Fallopian tube carcinosarcoma (FTCS) is an extremely rare and aggressive malignancy, its nonspecific clinical presentation and anatomical location make preoperative diagnosis challenging, often lead to delayed treatment and poor outcomes. Here, we present a case of early-stage FTCS in a 57-year-old postmenopausal woman who presented with vaginal bleeding. Transvaginal sonography (TVS) played a pivotal role in identifying a characteristic sausage-shaped adnexal mass, which was missed on enhanced computed tomography (ECT). The patient underwent comprehensive surgical staging, including total hysterectomy and bilateral adnexectomy, with pathology confirming FTCS, FIGO stage IA. Immunohistochemical analysis revealed a biphasic tumor with strong P53 positivity and a high Ki-67 index (80%), indicative of its aggressive nature. Despite declining adjuvant therapy beyond two cycles of chemotherapy, the patient remained recurrence-free at 24 months postoperatively. This case highlights the critical role of TVS in the early detection of FTCS and underscores the importance of timely surgical intervention in improving outcomes. We also discuss the diagnostic challenges, pathological features, and therapeutic considerations of FTCS, emphasizing the need for further research to optimize diagnostic and treatment strategies for this rare malignancy.
输卵管癌肉瘤（FTCS）是一种极其罕见且侵袭性强的恶性肿瘤，其非特异性临床表现和解剖位置使得术前诊断具有挑战性，常导致治疗延迟和预后不良。在此，我们报告一例57岁绝经后女性的早期FTCS病例，该患者表现为阴道出血。经阴道超声检查（TVS）在识别特征性的腊肠样附件包块方面发挥了关键作用，而增强计算机断层扫描（ECT）未发现该包块。患者接受了包括全子宫切除术和双侧附件切除术在内的全面手术分期，病理证实为FTCS，国际妇产科联盟（FIGO）分期IA期。免疫组化分析显示为双相肿瘤，P53强阳性且Ki-67指数高（80%），表明其具有侵袭性。尽管在两个周期化疗后拒绝辅助治疗，但患者术后24个月仍无复发。该病例突出了TVS在FTCS早期检测中的关键作用，并强调了及时手术干预对改善预后的重要性。我们还讨论了FTCS的诊断挑战、病理特征和治疗考虑因素，强调需要进一步研究以优化这种罕见恶性肿瘤的诊断和治疗策略。
