Enaholo Ehimare, Okoye Godwin, Musa Mutali, Suleman Ayuba, Ojo Oluwasola, Foti Roberta, D'Esposito Fabiana, Giglio Rosa, Tognetto Daniele, Gagliano Caterina, Zeppieri Marco
Department of Ophthalmology, Centre for Sight Africa Ltd, Nkpor 434101, Nigeria.
Department of Ophthalmology, Africa Eye Laser Center Ltd, Benin 300211, Nigeria.
World J Clin Cases. 2025 Oct 16;13(29):108046. doi: 10.12998/wjcc.v13.i29.108046.
High-resolution optical coherence tomography (HR-OCT) has become an essential instrument in the screening and diagnosis of ocular surface neoplasms. Research demonstrates that HR-OCT possesses a diagnostic sensitivity ranging from 85% to 90% for ocular surface squamous neoplasia (OSSN). The connections between HR-OCT features and histological findings have consistently shown robustness, hence increasing the reliability of clinical diagnosis.
To examine the existing HR-OCT indicators employed in the identification of common non-benign ocular surface tumors, namely, basal cell carcinoma, OSSN, and melanocytic conjunctival lesions, and to assess their diagnostic efficacy, benefits, and prospective developments.
A thorough literature review was performed to assess the published research on HR-OCT in the diagnosis of ocular surface cancers. Significant attention was given to research that compares HR-OCT characteristics with histopathologic validation, as well as on publications addressing the integration of emerging technologies and artificial intelligence in ocular oncology imaging.
HR-OCT exhibits elevated diagnostic sensitivity (85%-90%) for identifying OSSN and presents distinct imaging patterns that align closely with histology results. This approach has substantial clinical advantages due to its non-invasive characteristics, improved axial resolution, and real-time imaging capabilities. HR-OCT has demonstrated potential in assessing various lesions, including basal cell carcinoma and melanocytic conjunctival malignancies.
HR-OCT assumes an increasingly vital role in the early identification and clinical management of ocular surface malignancies. With advancements in imaging technology and the integration of artificial intelligence, HR-OCT is anticipated to enhance individualized diagnosis and treatment planning in ocular oncology, hence improving patient outcomes.
高分辨率光学相干断层扫描（HR-OCT）已成为眼表肿瘤筛查和诊断的重要工具。研究表明，HR-OCT对眼表鳞状上皮肿瘤（OSSN）的诊断敏感性为85%至90%。HR-OCT特征与组织学结果之间的联系一直很稳固，从而提高了临床诊断的可靠性。
研究用于识别常见非良性眼表肿瘤（即基底细胞癌、OSSN和结膜黑素细胞病变）的现有HR-OCT指标，并评估其诊断效能、优势和未来发展。
进行了全面的文献综述，以评估已发表的关于HR-OCT在眼表癌诊断中的研究。重点关注将HR-OCT特征与组织病理学验证进行比较的研究，以及涉及新兴技术和人工智能在眼科肿瘤成像中整合的出版物。
HR-OCT在识别OSSN方面具有较高的诊断敏感性（85% - 90%），并呈现出与组织学结果密切相符的独特成像模式。由于其非侵入性、更高的轴向分辨率和实时成像能力，这种方法具有显著的临床优势。HR-OCT在评估包括基底细胞癌和结膜黑素细胞恶性肿瘤在内的各种病变方面已显示出潜力。
HR-OCT在眼表恶性肿瘤的早期识别和临床管理中发挥着越来越重要的作用。随着成像技术的进步和人工智能的整合，预计HR-OCT将提高眼科肿瘤的个体化诊断和治疗规划，从而改善患者预后。
