Singapore National Eye Centre, Singapore 168751, Singapore.
Singapore Eye Research Institute, Singapore 168751, Singapore.
Medicina (Kaunas). 2024 Sep 28;60(10):1597. doi: 10.3390/medicina60101597.
Dye-based angiography is the main imaging modality in evaluating the vasculature of the eye. Although most commonly used to assess retinal vasculature, it can also delineate normal and abnormal blood vessels in the anterior segment diseases-but is limited due to its invasive, time-consuming methods. Thus, anterior segment optical coherence tomography angiography (AS-OCTA) is a useful non-invasive modality capable of producing high-resolution images to evaluate the cornea and ocular surface vasculature. AS-OCTA has demonstrated the potential to detect and delineate blood vessels in the anterior segment with quality images comparable to dye-based angiography. AS-OCTA has a diverse range of applications for the cornea and ocular surface, such as objective assessment of corneal neovascularization and response to various treatments; diagnosis and evaluation of ocular surface squamous neoplasia; and evaluation of ocular surface disease including limbal stem cell deficiency and ischemia. Our review aims to summarize the new developments and clinical applications of AS-OCTA for the cornea and ocular surface.
基于染料的血管造影术是评估眼部血管的主要成像方式。虽然它最常用于评估视网膜血管，但它也可以描绘前节疾病中的正常和异常血管 - 但由于其具有侵入性和耗时的方法而受到限制。因此，前段光学相干断层扫描血管造影术（AS-OCTA）是一种有用的非侵入性方式，能够产生高分辨率图像来评估角膜和眼表血管。AS-OCTA 已经显示出在质量图像方面具有与基于染料的血管造影术相当的潜力，以检测和描绘前节中的血管。AS-OCTA 在角膜和眼表面具有广泛的应用，例如角膜新生血管的客观评估及其对各种治疗的反应；眼表面鳞状细胞肿瘤的诊断和评估；以及包括角膜缘干细胞缺乏和缺血在内的眼表疾病的评估。我们的综述旨在总结 AS-OCTA 在角膜和眼表面的新进展和临床应用。
