Şener Seher, Atalay Erdal, Batu Ezgi Deniz, Tatar Cansu Ayten, Başaran Özge, Bilginer Yelda, Özen Seza
Division of Pediatric Rheumatology, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.
Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkiye.
Turk J Med Sci. 2025 Jun 14;55(4):826-836. doi: 10.55730/1300-0144.6034. eCollection 2025.
BACKGROUND/AIM: Childhood-onset arthritis may result from various rheumatic diseases. This study aimed to systematically evaluate their distribution and characteristics in a large pediatric cohort.
We retrospectively analyzed all pediatric patients who presented with arthritis to the pediatric rheumatology clinic between January 2000 and January 2023.
A total of 1713 pediatric patients who presented with arthritis were included in this study (median age at diagnosis: 6.8 years; F/M = 1.2). Most of the patients (n = 859, 50.1%) had juvenile idiopathic arthritis (JIA) (especially oligoarticular JIA). Patients with familial Mediterranean fever, comprising 277 individuals (16.2%) presented with arthritis. The majority of them (n = 203, 73.3%) had short-lasting recurrent oligoarthritis (mostly monoarthritis) attacks. While arthritis was observed in 236 (13.8%) patients with vasculitis, immunoglobulin A vasculitis was the most common cause among them (n = 166, 70.3%). Most of the vasculitis patients had oligoarthritis (n = 221, 93.6%). Reactive arthritis was present in 147 patients (8.6%, mostly monoarthritis). Acute rheumatic fever was another cause of arthritis (4.7%, mostly polyarticular and migratory). Among autoimmune diseases (mostly systemic lupus erythematosus), arthritis was detected in 82 patients (4.8%, oligoarthritis or polyarthritis).
In our study, we focused on the rheumatic etiologies underlying childhood arthritis. Given the heterogeneity of etiologies, clinical evaluation should be comprehensive, considering systemic features beyond joint involvement.
背景/目的：儿童期发病的关节炎可能由多种风湿性疾病引起。本研究旨在系统评估其在一个大型儿科队列中的分布和特征。
我们回顾性分析了2000年1月至2023年1月期间到儿科风湿病诊所就诊的所有患有关节炎的儿科患者。
本研究共纳入1713例患有关节炎的儿科患者（诊断时的中位年龄：6.8岁；女性/男性 = 1.2）。大多数患者（n = 859，50.1%）患有幼年特发性关节炎（JIA）（尤其是少关节型JIA）。277例（16.2%）家族性地中海热患者出现关节炎。其中大多数（n = 203，73.3%）有短暂复发性少关节炎（大多为单关节炎）发作。236例（13.8%）血管炎患者出现关节炎，其中免疫球蛋白A血管炎是最常见的病因（n = 166，70.3%）。大多数血管炎患者患有少关节炎（n = 221，93.6%）。147例患者（8.6%，大多为单关节炎）患有反应性关节炎。急性风湿热是关节炎的另一个病因（4.7%，大多为多关节和游走性）。在自身免疫性疾病（大多为系统性红斑狼疮）中，82例患者（4.8%）检测到关节炎（少关节炎或多关节炎）。
在我们的研究中，我们关注儿童关节炎的风湿病因。鉴于病因的异质性，临床评估应全面，考虑关节受累以外的全身特征。
