Zuo Wei, Xiao Yongjian, Xiang Qing, Xiao Shuangwen, Xie Yafeng
Department of Clinical Laboratory, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.
Front Immunol. 2025 Aug 26;16:1632677. doi: 10.3389/fimmu.2025.1632677. eCollection 2025.
is the causative agent of syphilis, a chronic sexually transmitted disease that leads to widespread organ damage. The pathogenesis of syphilis involves crucial functional proteins that facilitate bacterial adhesion to host cells, invasion, dissemination, immune evasion, and inflammatory responses. Investigating these proteins is crucial for the development of innovative diagnostic tools, vaccines, and therapies. However, the intricate nature of and the inability to culture hinder our comprehensive understanding of these proteins. This review article presents innovative understandings of the pathogenesis of functional proteins, building upon existing knowledge. This paper establishes a foundation for comprehending the current knowledge landscape and outlining future research avenues.
是梅毒的病原体，梅毒是一种慢性性传播疾病，会导致广泛的器官损害。梅毒的发病机制涉及关键功能蛋白，这些蛋白有助于细菌粘附于宿主细胞、侵入、传播、免疫逃逸和炎症反应。研究这些蛋白对于开发创新的诊断工具、疫苗和治疗方法至关重要。然而，其复杂的性质以及无法培养的情况阻碍了我们对这些蛋白的全面理解。这篇综述文章在现有知识的基础上，对功能性蛋白的发病机制提出了创新性的理解。本文为理解当前的知识格局和勾勒未来的研究途径奠定了基础。
需注意，原文中部分关键内容缺失，比如缺失具体的病原体名称等，上述译文是在尽量按照正确逻辑翻译的基础上，根据现有内容补全以使译文完整。
