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Near-Universal Resistance to Macrolides of in North America.北美地区肺炎支原体对大环内酯类药物几乎普遍耐药。
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Macrolide resistance in Treponema pallidum in the United States and Ireland.美国和爱尔兰梅毒螺旋体对大环内酯类药物的耐药性
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Azithromycin versus penicillin G benzathine for early syphilis.阿奇霉素与苄星青霉素治疗早期梅毒的对比
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Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy.早期梅毒的HIV阳性患者中的吉海反应:阿奇霉素与苄星青霉素G治疗对比
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Comparison of serological responses to single-dose azithromycin (2 g) versus benzathine penicillin G in the treatment of early syphilis in HIV-infected patients in an area of low prevalence of macrolide-resistant Treponema pallidum infection.比较在低耐大环内酯类梅毒密螺旋体感染流行地区,单次剂量阿奇霉素(2 g)与苄星青霉素 G 治疗 HIV 感染患者早期梅毒的血清学反应。
J Antimicrob Chemother. 2016 Mar;71(3):775-82. doi: 10.1093/jac/dkv379. Epub 2015 Nov 24.
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Macrolide Resistance in Treponema pallidum Correlates With 23S rDNA Mutations in Recently Isolated Clinical Strains.梅毒螺旋体对大环内酯类药物的耐药性与近期分离的临床菌株中的23S rDNA突变相关。
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First Report of the 23S rRNA Gene A2058G Point Mutation Associated With Macrolide Resistance in Treponema pallidum From Syphilis Patients in Cuba.古巴梅毒患者中与梅毒螺旋体大环内酯耐药相关的23S rRNA基因A2058G点突变的首次报告
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Azithromycin resistance in Treponema pallidum.梅毒螺旋体对阿奇霉素的耐药性。
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High frequency of the 23S rRNA A2058G mutation of Treponema pallidum in Shanghai is associated with a current strategy for the treatment of syphilis.上海梅毒螺旋体23S rRNA A2058G突变的高频率与当前梅毒治疗策略有关。
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Azithromycin resistance in Treponema pallidum.梅毒螺旋体对阿奇霉素的耐药性。
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A new typing scheme demonstrates high discriminatory power for subspecies.一种新的分型方案对亚种具有高度的鉴别力。
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Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic.梅毒诊断技术进展应对21世纪疫情
Clin Chem. 2025 Sep 3;71(9):935-948. doi: 10.1093/clinchem/hvaf072.
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Resurgence of syphilis among blood donors in a single institute in Eastern India: a looming threat to public health and transfusion services.印度东部一家机构献血者中梅毒感染率回升:对公共卫生和输血服务的潜在威胁。
Lancet Reg Health Southeast Asia. 2025 Mar 31;36:100572. doi: 10.1016/j.lansea.2025.100572. eCollection 2025 May.
4
Establishment of the Nichols strain as the type strain of .将尼科尔斯菌株确立为……的模式菌株。 (原句似乎不完整,缺少具体的菌株所属类别等信息)
Int J Syst Evol Microbiol. 2025 Feb;75(2). doi: 10.1099/ijsem.0.006697.
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Antimicrobial Resistance in Curable Sexually Transmitted Infections.可治愈性传播感染中的抗菌药物耐药性
Curr HIV/AIDS Rep. 2025 Jan 25;22(1):14. doi: 10.1007/s11904-025-00722-7.
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Put a little doxy-PEP in your step: Using doxycycline to prevent chlamydia, syphilis, and gonorrhea infections.在你的行动中加入一点强力霉素暴露后预防:使用强力霉素预防衣原体、梅毒和淋病感染。
PLoS Pathog. 2024 Sep 30;20(9):e1012575. doi: 10.1371/journal.ppat.1012575. eCollection 2024 Sep.
7
Syphilis on the rise - a need for alternative therapies and vaccines.梅毒发病率上升——对替代疗法和疫苗的需求
Nat Rev Urol. 2024 Aug;21(8):457. doi: 10.1038/s41585-024-00916-5.

本文引用的文献

1
Antimicrobial susceptibility of Treponema pallidum subspecies pallidum: an in-vitro study.苍白密螺旋体亚种苍白密螺旋体的抗菌药敏性:体外研究。
Lancet Microbe. 2023 Dec;4(12):e994-e1004. doi: 10.1016/S2666-5247(23)00219-7. Epub 2023 Oct 9.
2
Genomic epidemiology of syphilis in England: a population-based study.梅毒的基因组流行病学研究:基于人群的研究。
Lancet Microbe. 2023 Oct;4(10):e770-e780. doi: 10.1016/S2666-5247(23)00154-4. Epub 2023 Sep 15.
3
Sexually Transmitted Infections Treatment Guidelines, 2021.《2021年性传播感染治疗指南》
MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. doi: 10.15585/mmwr.rr7004a1.
4
Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009.2007 年至 2009 年美国梅毒螺旋体 23S rRNA A2058G 点突变及分子亚型的流行情况。
Sex Transm Dis. 2012 Oct;39(10):794-8. doi: 10.1097/OLQ.0b013e31826f36de.

Near-Universal Resistance to Macrolides of in North America.

作者信息

Lieberman Nicole A P, Reid Tara B, Cannon Chase A, Nunley B Ethan, Berzkalns Anna, Cohen Stephanie E, Newman Lori M, Aldrete Sol, Xu Linda H, Thornlund Clinton P, Pettus Kevin, Lundy Stephanie, Kron Michael, Soge Olusegun O, Workowski Kimberly, Perlowski Charlotte, Hook Edward W, Dionne Jodie A, Golden Matthew R, Lieberman Joshua A, Lee Min-Kuang, Morshed Muhammad, Naidu Prenilla, Cao Weiping, Pillay Allan, Giacani Lorenzo, Greninger Alexander L

机构信息

University of Washington, Seattle, WA

Public Health - Seattle and King County, Seattle, WA.

出版信息

N Engl J Med. 2024 Jun 13;390(22):2127-2128. doi: 10.1056/NEJMc2314441.

DOI:10.1056/NEJMc2314441
PMID:38865666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345850/
Abstract
摘要