Thimoteo Anna Carolina Pereira, de Oliveira Júlia Meller Dias, Polmann Helena, Pauletto Patrícia, Stefani Cristine Miron, De Luca Canto Graziela, Bohner Lauren
Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
PLoS One. 2025 Sep 11;20(9):e0331581. doi: 10.1371/journal.pone.0331581. eCollection 2025.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by the primary symptoms of inattention, disorganization, and/or hyperactivity-impulsivity. Bruxism is a repetitive activity of the chewing muscles characterized by clenching and grinding of the teeth and forceful mandibular movements. Various physiological and psychosocial factors, including attention deficit, depression, stress, and anxiety, have been associated with bruxism. The aim of this systematic review protocol is facilitating the understanding of the systematic review methods and promote transparency in the research. The systematic review will investigate whether there is evidence regarding the association between ADHD and bruxism. The search will be conducted on six databases. Gray literature will be explored through Google Scholar and ProQuest Dissertations & Theses Global. Lists of references of included studies and experts in the field will be consulted. Observational studies that present data comparing a group of individuals with ADHD and a group of individuals without ADHD as well as an analysis of the presence of bruxism will be included. Included studies can detect bruxism based only on a positive self-report (or parental report), clinical inspection, or instrumental assessment. The selection of studies will occur in two phases by two authors. The risk of bias in the included studies will be assessed using JBI tools. A narrative synthesis will be performed. If feasible, a quantitative synthesis will be carried out through pairwise meta-analysis. Odds ratios with 95% confidence intervals will be calculated using the random effects model. This protocol is characterized by its rigorous methodology, which involves an exhaustive search across six databases, as well as gray literature sources, reference lists, and expert consultation, thereby augmenting the comprehensiveness and reliability of the findings. This protocol was registered in PROSPERO under the number CRD42024538099.
注意缺陷多动障碍（ADHD）是一种神经发育障碍，其主要症状为注意力不集中、行为紊乱和/或多动冲动。磨牙症是咀嚼肌的一种重复性活动，其特征为牙齿紧咬、磨动以及有力的下颌运动。包括注意力缺陷、抑郁、压力和焦虑在内的各种生理和心理社会因素都与磨牙症有关。本系统评价方案的目的是促进对系统评价方法的理解，并提高研究的透明度。该系统评价将调查是否有证据表明ADHD与磨牙症之间存在关联。将在六个数据库中进行检索。将通过谷歌学术和ProQuest全球博硕士论文库探索灰色文献。将查阅纳入研究的参考文献列表以及该领域的专家。纳入的观察性研究需呈现比较一组ADHD患者和一组非ADHD患者的数据，以及对磨牙症存在情况的分析。纳入的研究可以仅基于阳性自我报告（或家长报告）、临床检查或仪器评估来检测磨牙症。研究的选择将由两位作者分两个阶段进行。将使用JBI工具评估纳入研究的偏倚风险。将进行叙述性综合分析。如果可行，将通过成对荟萃分析进行定量综合分析。将使用随机效应模型计算95%置信区间的比值比。本方案的特点是其严谨的方法，包括在六个数据库以及灰色文献来源、参考文献列表和专家咨询中进行详尽搜索，从而提高研究结果的全面性和可靠性。本方案已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号为CRD42024538099。
