Dizerens P, Anani P, Gómez F, De Grandi P
J Gynecol Obstet Biol Reprod (Paris). 1985;14(7):843-59.
This retrospective study on 545 primary mammary carcinomas shows highly significant negative correlations between the presence of oestrogen and progesterone receptors on the one hand and nuclear grading, degree of necrosis or of inflammatory infiltration and histological grading on the other hand. The relationship between receptors and histological grading is not as highly significant as reported by others because of the criteria of grading that were selected. All these correlations disappear when only premenopausal patients are considered. Receptors are most frequently positive in tubular and lobular carcinomas but are rarely found in medullary carcinoma. The presence of receptors bears no link with the size of the tumour. When a tumour is too small for both, histopathological and biochemical analysis to be performed, it is possible to predict the existence of positive receptors thanks to histological criteria of tumour differentiation with a probability of 75% for 67% of patients.
这项针对545例原发性乳腺癌的回顾性研究表明，一方面雌激素和孕激素受体的存在与另一方面的核分级、坏死程度或炎症浸润以及组织学分级之间存在高度显著的负相关。由于所选择的分级标准，受体与组织学分级之间的关系不如其他人报道的那样高度显著。当仅考虑绝经前患者时，所有这些相关性均消失。受体在管状癌和小叶癌中最常呈阳性，但在髓样癌中很少见。受体的存在与肿瘤大小无关。当肿瘤太小而无法进行组织病理学和生化分析时，借助肿瘤分化的组织学标准可以预测阳性受体的存在，67%的患者预测概率为75%。
