Wu Zeming, Qu Jing, Zhang Weiqi, Liu Guang-Hui
State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
School of Life Sciences, Jilin University, Changchun, China.
Nat Rev Mol Cell Biol. 2025 Sep 11. doi: 10.1038/s41580-025-00883-8.
Ageing is characterized by progressive functional decline and increase in disease risk and imposes substantial burdens on human health. Identifying aging biomarkers in primates is crucial for advancing our understanding of human ageing and for informing interventions to mitigate age-related pathologies. However, a comprehensive grasp of these biomarkers is still lacking, hindering the translation of fundamental research into clinical practice. In this Review, we present the current knowledge on biomarkers of ageing at the cellular, tissue and organism levels in humans and non-human primates. Through systematic analysis of representative biomarkers across diverse biological contexts and scales, we discuss both the variability and the conservation of ageing-associated physiological changes, underscoring their importance in assessing and intervening in the ageing process. Finally, we critically assess challenges in ageing research and outline strategic avenues for future investigation.
衰老的特征是功能逐渐衰退和疾病风险增加，给人类健康带来巨大负担。识别灵长类动物的衰老生物标志物对于增进我们对人类衰老的理解以及为减轻与年龄相关的病理状况的干预措施提供依据至关重要。然而，目前仍缺乏对这些生物标志物的全面了解，这阻碍了基础研究向临床实践的转化。在本综述中，我们介绍了人类和非人类灵长类动物在细胞、组织和生物体水平上衰老生物标志物的现有知识。通过对不同生物学背景和尺度下代表性生物标志物的系统分析，我们讨论了衰老相关生理变化的变异性和保守性，强调了它们在评估和干预衰老过程中的重要性。最后，我们批判性地评估了衰老研究中的挑战，并概述了未来研究的战略方向。
