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肾移植受者真菌血症罕见病例:病例报告

A Rare Case of Fungemia in a Kidney Transplant Recipient: A Case Report.

作者信息

Patil Jayaditya Devpal, Sogawa Hiroshi, Mulligan David

机构信息

Department of Surgery, Yale New Haven Hospital, New Haven, Connecticut, USA.

Division of Transplantation in the Department of Surgery, Yale New Haven Hospital, New Haven, Connecticut, USA.

出版信息

Case Rep Transplant. 2025 Jul 28;2025:3478928. doi: 10.1155/crit/3478928. eCollection 2025.

Abstract

Despite revolutionary improvements in mortality, cardiovascular events, and quality of life, kidney transplantation has been plagued with perioperative mortality, graft rejection, and immunosuppression-associated complications, most commonly infections. Fungal infections in particular only account for 5% of all cases but have the worst outcomes, with mortality ranging between 25% and 80% in solid organ transplant recipients. , , and species are the commonest causative agents, and isolated cases of other species have been reported in other immunosuppressed pathologies. Here, we present the first recorded case of fungemia in a kidney transplant recipient, highlighting the need for close surveillance, early diagnosis, and potentially continuing posttransplant antifungal prophylaxis beyond the current recommended duration.

摘要

尽管在死亡率、心血管事件和生活质量方面取得了革命性的进步,但肾移植一直受到围手术期死亡率、移植排斥反应和免疫抑制相关并发症的困扰,其中最常见的是感染。特别是真菌感染仅占所有病例的5%,但后果最为严重,实体器官移植受者的死亡率在25%至80%之间。 、 和 种是最常见的病原体,在其他免疫抑制性疾病中也报告了其他菌种的个别病例。在此,我们报告了首例肾移植受者发生 菌血症的病例,强调了密切监测、早期诊断的必要性,以及可能需要在当前推荐疗程之外继续进行移植后抗真菌预防。

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A Rare Case of Fungemia in a Kidney Transplant Recipient: A Case Report.肾移植受者真菌血症罕见病例:病例报告
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本文引用的文献

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Global incidence and mortality of severe fungal disease.全球严重真菌感染的发病率和死亡率。
Lancet Infect Dis. 2024 Jul;24(7):e428-e438. doi: 10.1016/S1473-3099(23)00692-8. Epub 2024 Jan 12.
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Long-Term Infectious Complications of Kidney Transplantation.肾移植的长期感染性并发症。
Clin J Am Soc Nephrol. 2022 Feb;17(2):286-295. doi: 10.2215/CJN.15971020. Epub 2021 Apr 20.
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Invasive Pulmonary Aspergillosis.侵袭性肺曲霉病。
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