Anastasopoulos Lykourgos, Charalampopoulou Eirini, Argyrakos Theodoros, Bourlogiannis Fotis, Korfias Stefanos
1st University Department of Neurosurgery, General Hospital of Athens Evangelismos, Athens, Greece.
Athens Microneurosurgery Laboratory, Evangelismos Hospital, Athens, Greece.
Front Oncol. 2025 Aug 27;15:1638461. doi: 10.3389/fonc.2025.1638461. eCollection 2025.
Primary central nervous system T-cell lymphoma (PCNS-TCL) is an exceptionally rare entity, representing less than 5% of all PCNSLs. Its diagnosis is frequently delayed due to nonspecific radiologic features and an often absent or poor response to corticosteroid therapy. Here, we present a unique case of an immunocompetent 58-year-old male with a solitary, EBV-positive, T-cell lymphoma localized in the right temporal lobe. The lesion was refractory to corticosteroid therapy and ultimately required gross total resection (GTR) due to progressive neurological deterioration. Postoperative histopathological examination confirmed a cytotoxic T-cell phenotype with EBV positivity. The patient demonstrated immediate neurological improvement post-surgery. This case underscores the importance of considering T-cell lymphoma in the differential diagnosis of solitary intracranial masses and suggests that surgical intervention may be warranted in select cases.
原发性中枢神经系统T细胞淋巴瘤（PCNS-TCL）是一种极其罕见的疾病，占所有原发性中枢神经系统淋巴瘤（PCNSL）的比例不到5%。由于其影像学特征不具特异性，且对皮质类固醇治疗通常无反应或反应不佳，其诊断常常被延误。在此，我们报告一例独特病例，一名58岁免疫功能正常的男性，患有位于右侧颞叶的孤立性、EBV阳性T细胞淋巴瘤。该病变对皮质类固醇治疗无效，由于进行性神经功能恶化，最终需要进行全切除（GTR）。术后组织病理学检查证实为具有EBV阳性的细胞毒性T细胞表型。患者术后神经功能立即得到改善。该病例强调了在孤立性颅内肿块的鉴别诊断中考虑T细胞淋巴瘤的重要性，并表明在某些情况下手术干预可能是必要的。
