Tan Mengnan, Xu Jie, Dong Wei
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China CDC Wkly. 2025 Aug 22;7(34):1099-1105. doi: 10.46234/ccdcw2025.185.
Human Immunodeficiency Virus (HIV) nonoccupational post-exposure prophylaxis (nPEP) clinics are specialized healthcare facilities that provide urgent medical interventions to individuals with potential high-risk HIV exposures. This study analyzed utilization patterns of HIV nPEP services in China and examined factors associated with medication adherence among consultees, providing evidence to inform further implementation and optimization of HIV nPEP interventions.
We analyzed nPEP case data collected from the national nPEP data information system between November 1, 2022, and November 1, 2024, using SPSS 29.0 software. Chi-square tests were applied to analyze characteristics of nPEP consultees, and logistic regression models were used to identify factors influencing medication adherence and follow-up compliance among those who initiated treatment.
As of November 1, 2024, 924 nPEP clinics nationwide received 54,108 consultees, with 53,405 (98.70%) initiating medication. Most individuals seeking services were male (88.63%), classified as high-risk (83.11%), and heterosexual with multiple partners (67.66%). The "BIC/FTC/TAF" regimen was selected by 63.07% of recipients. Nearly all users (99.03%) completed medication evaluation within 72 hours post-exposure. Among medication users, 60.34% (30,650) adhered to the full 28-day regimen, and 60.10% (30,509) completed either one-month or three-month follow-ups. Multivariate logistic regression analysis identified gender, exposure risk assessment results, exposure population classification, individual preferences, and medication regimen as significant factors influencing both 28-day medication adherence and follow-up compliance (<0.05).
nPEP clinic consultees in China are predominantly young male heterosexual individuals with multiple sexual partners, with most selecting the Biktarvy regimen. However, both current 28-day medication adherence and follow-up compliance rates remain suboptimal. High-risk men and those receiving the Biktarvy regimen demonstrate superior medication adherence and follow-up compliance compared to other groups. Further research is needed to develop targeted interventions to improve medication adherence and follow-up rates among nPEP recipients. Enhancing adherence and follow-up should be prioritized in future interventions, supported by continuous monitoring to inform timely intervention strategy adjustments.
人类免疫缺陷病毒（HIV）非职业性暴露后预防（nPEP）诊所是专门的医疗机构，为有潜在高风险HIV暴露的个体提供紧急医疗干预。本研究分析了中国HIV nPEP服务的利用模式，并调查了咨询者中与药物依从性相关的因素，为进一步实施和优化HIV nPEP干预措施提供依据。
我们使用SPSS 29.0软件分析了2022年11月1日至2024年11月1日期间从国家nPEP数据信息系统收集的nPEP病例数据。采用卡方检验分析nPEP咨询者的特征，并使用逻辑回归模型确定影响开始治疗者药物依从性和随访依从性的因素。
截至2024年11月1日，全国924家nPEP诊所接待了54108名咨询者，其中53405人（98.70%）开始用药。寻求服务的大多数个体为男性（88.63%），属于高风险人群（83.11%），且为有多个性伴侣的异性恋者（67.66%）。63.07%的接受者选择了“比克恩丙诺片/恩曲他滨替诺福韦片”（BIC/FTC/TAF）方案。几乎所有使用者（99.03%）在暴露后72小时内完成了用药评估。在用药者中，60.34%（30650人）坚持完成了整个28天疗程，60.10%（30509人）完成了1个月或3个月的随访。多因素逻辑回归分析确定性别、暴露风险评估结果、暴露人群分类、个人偏好和用药方案是影响28天药物依从性和随访依从性的重要因素（<0.05）。
中国nPEP诊所的咨询者主要是有多个性伴侣的年轻男性异性恋者，大多数选择比克恩丙诺片方案。然而，目前28天的药物依从率和随访依从率仍不理想。与其他组相比，高风险男性和接受比克恩丙诺片方案的人群表现出更好的药物依从性和随访依从性。需要进一步研究制定针对性干预措施，以提高nPEP接受者的药物依从性和随访率。在未来的干预中应优先提高依从性和随访率，并通过持续监测为及时调整干预策略提供支持。
