Sosnowska-Sienkiewicz Patrycja, Błaszczyk Kinga, Kubisiak-Rzepczyk Honorata, Mańkowski Przemysław, Januszkiewicz-Lewandowska Danuta
Department of Pediatric Surgery, Traumatology and Urology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Medical Diagnostic, Poznan, Poland.
Front Med (Lausanne). 2022 Feb 25;9:844880. doi: 10.3389/fmed.2022.844880. eCollection 2022.
Mucormycosis is a rare but a devastating and lifethreatening fungal infection caused by fungi of the order Mucorales usually in immunocompromised patients. Depending on the organs and tissues involved, there are sinus, pulmonary, gastrointestinal, orbital, cerebral, cutaneous and disseminated mucormycosis. Only sporadic cases of hepatic mucormycosis have been described. Hence, we present a complicated treatment management in a 16-month-old child with leukemia and generalized mucormycosis localized in the liver and in the gastrointestinal tract. The collaboration of a multidisciplinary team and appropriate therapy gave a chance not only to save the patient's life, but to carry out anticancer treatment, which resulted in leukemia remission. A 6-month course of isavuconazole and amphotericin B liposomal as well as surgical treatment led to the cure of the fungal infection.
毛霉病是一种罕见但具有毁灭性且危及生命的真菌感染，通常由毛霉目真菌引起，多见于免疫功能低下的患者。根据受累的器官和组织不同，有鼻窦型、肺型、胃肠型、眼眶型、脑型、皮肤型和播散型毛霉病。仅有散发性肝毛霉病病例的报道。因此，我们介绍了一名16个月大患白血病且肝脏和胃肠道发生播散性毛霉病患儿的复杂治疗过程。多学科团队的协作及恰当的治疗不仅挽救了患者生命，还得以开展抗癌治疗，使白血病缓解。6个月的艾沙康唑和两性霉素B脂质体疗程以及手术治疗使真菌感染得以治愈。
