Chen Ya-Yu, Yang Ren-Yu, Sun Han-Yin
Department of Optometry, MacKay Medical College, New Taipei City, Taiwan.
Department of Optometry, Chung Shan Medical University, Taichung City, Taiwan.
Clin Ophthalmol. 2025 Sep 6;19:3273-3281. doi: 10.2147/OPTH.S538886. eCollection 2025.
To evaluate both subjective grading and objective assessments associated with switching from habitual silicone hydrogel daily disposable contact lenses to verofilcon A lenses (study lenses) among young Asian individuals, and to investigate the relationship between these subjective and objective measures.
58 participants wore study lenses for 8-10 hours daily for a week. Subjective assessments, including comfort, visual quality, and eye dryness, were conducted using a numerical rating scale (0-100) on the first and seventh day. Noninvasive tear breakup time (NITBUT), bulbar conjunctival redness (BR), tear meniscus height (TMH), and meibography were measured with the Keratograph M5 at baseline, the first and the seventh day.
After the seventh day, subjective ratings showed increased comfort and decreased visual quality and dryness. Comfort and visual quality scores on the first and seventh days were above 85 points, with no significant differences. The average NITBUT significantly improved 15 minutes and 8 hours post-lens application compared to baseline measures ( = 0.019). Tear meniscus height was highest at baseline, with a marginal decrease observed following both 15 minutes and 8 hours of study lenses wear ( < 0.001). The most pronounced bulbar conjunctival redness was noted at baseline, decreasing significantly after switching to study lenses ( = 0.002). Notably, NITBUT was found to be significantly positively correlated with comfort ( < 0.05).
The switch to daily disposable study lenses resulted in maintained comfort and improved tear film stability in the young Asian population. A significant positive correlation was observed between NITBUT and subjective measures of comfort.
评估年轻亚洲人从习惯性使用硅水凝胶日抛型隐形眼镜转换为使用verofilcon A镜片(研究镜片)后的主观评分和客观评估,并研究这些主观和客观指标之间的关系。
58名参与者每天佩戴研究镜片8 - 10小时,持续一周。在第一天和第七天使用数字评分量表(0 - 100)进行主观评估,包括舒适度、视觉质量和眼干程度。使用角膜地形图仪M5在基线、第一天和第七天测量无创泪膜破裂时间(NITBUT)、球结膜充血(BR)、泪河高度(TMH)和睑板腺造影。
第七天后,主观评分显示舒适度增加,视觉质量和眼干程度下降。第一天和第七天的舒适度和视觉质量评分均高于85分,无显著差异。与基线测量相比,佩戴镜片后15分钟和8小时时平均NITBUT显著改善(P = 0.019)。泪河高度在基线时最高,佩戴研究镜片15分钟和8小时后均有轻微下降(P < 0.001)。球结膜充血在基线时最为明显,转换为研究镜片后显著下降(P = 0.002)。值得注意的是,发现NITBUT与舒适度显著正相关(P < 0.05)。
转换为日抛型研究镜片可使年轻亚洲人群维持舒适度并改善泪膜稳定性。NITBUT与舒适度的主观指标之间存在显著正相关。