Zhu Lirong, Liu Qianqian, Zhao Chao, Zhu Meichen, Yang Xuewei, Yang Jinkui
State Key Laboratory for Conservation and Utilization of Bio-Resources, Key Laboratory for Microbial Resources of the Ministry of Education, School of Life Sciences, Yunnan University, Kunming, China.
Mycology. 2025 Jan 6;16(3):988-1010. doi: 10.1080/21501203.2024.2425170. eCollection 2025.
Chromatin remodellers utilise energy generated from ATP hydrolysis to remodel nucleosomes and modulate histones, which are crucial for eukaryotic gene expression and chromatin architecture. The SWI/SNF (switching defective/sucrose non-fermenting) class of ATP-dependent chromatin modifiers in eukaryotes includes two complexes, SWI/SNF and RSC (remodeling the structure of chromatin). In the past 10 years, SWI/SNF and RSC chromatin remodellers have been a focus of research in various organisms, including animals, plants and fungi. In fungi, these two complexes have multiple functions, including roles in regulating hyphal differentiation, sporulation, stress responses, and pathogenicity. In addition to describing conserved structural properties and mechanisms of action, we highlight evidence for sequence and functional divergence in fungal evolution. This review provides a basis for further comparative analyses of the roles and regulatory mechanisms of the SWI/SNF and RSC complexes in taxonomically diverse fungi, laying a good foundation for potential applications in controlling pathogenic fungi.
染色质重塑因子利用ATP水解产生的能量来重塑核小体并调节组蛋白，这对于真核基因表达和染色质结构至关重要。真核生物中依赖ATP的染色质修饰因子的SWI/SNF（转换缺陷/蔗糖不发酵）类别包括两种复合物，即SWI/SNF和RSC（重塑染色质结构）。在过去十年中，SWI/SNF和RSC染色质重塑因子一直是包括动物、植物和真菌在内的各种生物体研究的焦点。在真菌中，这两种复合物具有多种功能，包括在调节菌丝分化、孢子形成、应激反应和致病性方面的作用。除了描述保守的结构特性和作用机制外，我们还强调了真菌进化过程中序列和功能差异的证据。本综述为进一步比较分析SWI/SNF和RSC复合物在分类学上不同的真菌中的作用和调控机制提供了基础，为控制致病真菌的潜在应用奠定了良好的基础。
