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Mechanism of action of the SWI/SNF family complexes.

作者信息

Chen Kangjing, Yuan Junjie, Sia Youyang, Chen Zhucheng

机构信息

MOE Key Laboratory of Protein Science, Tsinghua University, Beijing, P.R. China.

School of Life Sciences, Tsinghua University, Beijing, P.R. China.

出版信息

Nucleus. 2023 Dec;14(1):2165604. doi: 10.1080/19491034.2023.2165604.

DOI:10.1080/19491034.2023.2165604
PMID:36633435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9839376/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/90019581b2a6/KNCL_A_2165604_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/40517c9c771f/KNCL_A_2165604_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/bb87f6fadd11/KNCL_A_2165604_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/8b0104fb3970/KNCL_A_2165604_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/90019581b2a6/KNCL_A_2165604_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/40517c9c771f/KNCL_A_2165604_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/bb87f6fadd11/KNCL_A_2165604_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/8b0104fb3970/KNCL_A_2165604_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c65e/9839376/90019581b2a6/KNCL_A_2165604_F0004_OC.jpg

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本文引用的文献

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2
SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma.SMARCE1 缺失在透明细胞脑膜瘤中产生可靶向的 mSWI/SNF 依赖性。
Nat Genet. 2022 Jun;54(6):861-873. doi: 10.1038/s41588-022-01077-0. Epub 2022 Jun 9.
3
Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.人染色质重塑 PBAF 复合物与核小体结合的结构。
J Clin Med. 2025 Apr 23;14(9):2898. doi: 10.3390/jcm14092898.
4
The epigenetic mechanisms involved in the treatment resistance of glioblastoma.胶质母细胞瘤治疗耐药性涉及的表观遗传机制。
Cancer Drug Resist. 2025 Mar 13;8:12. doi: 10.20517/cdr.2024.157. eCollection 2025.
5
Beyond the mono-nucleosome.超越单核小体。
Biochem Soc Trans. 2025 Jan 31;53(1):BCJ20240452. doi: 10.1042/BST20230721.
6
Tumor energy metabolism: implications for therapeutic targets.肿瘤能量代谢：治疗靶点的意义。
Mol Biomed. 2024 Nov 29;5(1):63. doi: 10.1186/s43556-024-00229-4.
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Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression.Swi/Snf染色质重塑调节转录干扰和基因抑制。
Mol Cell. 2024 Aug 22;84(16):3080-3097.e9. doi: 10.1016/j.molcel.2024.06.029. Epub 2024 Jul 22.
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SWI/SNF Complex Connects Signaling and Epigenetic State in Cells of Nervous System.SWI/SNF复合物在神经系统细胞中连接信号传导与表观遗传状态。
Mol Neurobiol. 2025 Feb;62(2):1536-1557. doi: 10.1007/s12035-024-04355-6. Epub 2024 Jul 13.
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Nucleus. 2024 Dec;15(1):2325961. doi: 10.1080/19491034.2024.2325961. Epub 2024 Mar 11.
Nature. 2022 May;605(7908):166-171. doi: 10.1038/s41586-022-04658-5. Epub 2022 Apr 27.
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Nature. 2022 Jan;601(7893):434-439. doi: 10.1038/s41586-021-04246-z. Epub 2021 Dec 22.
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Science. 2021 Jul 16;373(6552):306-315. doi: 10.1126/science.abf8705.
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Curr Opin Struct Biol. 2021 Dec;71:16-26. doi: 10.1016/j.sbi.2021.05.006. Epub 2021 Jun 28.
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SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.SWI/SNF 亚基 BAF155 N 端结构阐明了癌症相关突变的影响，并揭示了一个潜在的药物结合位点。
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