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颌骨外巨细胞肉芽肿作为婴儿眶周肿物的罕见病因：一例报告

Extragnathic Giant Cell Granuloma as a Rare Consideration for a Periorbital Mass in an Infant: A Case Report.

作者信息

Cepeda De Jesus Gabriela N, Hidalgo Cedeno Ernest F, Malhotra Ajay

机构信息

Department of Radiology, Hartford Hospital, Hartford, USA.

Department of Pathology, Yale School of Medicine, New Haven, USA.

出版信息

Cureus. 2025 Aug 11;17(8):e89820. doi: 10.7759/cureus.89820. eCollection 2025 Aug.

DOI:10.7759/cureus.89820
PMID:40937211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12422397/
Abstract

Giant cell granulomas (GCGs) are a benign condition that commonly affects females in their first and second decades of life and almost exclusively involves the jaws. We describe a rare presentation of a GCG involving the zygomatic bone in a five-month-old infant, an exceedingly uncommon location and age group for this entity. While GCGs are most frequently seen in the mandible or maxilla of young females, to our knowledge, there are no previous reports describing zygomatic involvement in this age group. Through detailed multimodality imaging, surgical pathology, and clinical follow-up, we highlight the diagnostic considerations, recurrence potential, and role of adjuvant therapy in managing this lesion.

摘要

巨细胞肉芽肿（GCGs）是一种良性疾病，通常影响10至20岁的女性，几乎仅累及颌骨。我们描述了一例罕见的病例，一名5个月大的婴儿的颧骨出现了巨细胞肉芽肿，这对于该疾病来说是极其罕见的发病部位和年龄组。虽然巨细胞肉芽肿最常见于年轻女性的下颌骨或上颌骨，但据我们所知，此前尚无关于该年龄组颧骨受累的报道。通过详细的多模态影像学检查、手术病理学检查及临床随访，我们强调了在处理该病变时的诊断要点、复发可能性及辅助治疗的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/001cf56cd014/cureus-0017-00000089820-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/b35b18bd1424/cureus-0017-00000089820-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/b5676c53db30/cureus-0017-00000089820-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/4b1d9a1e19e3/cureus-0017-00000089820-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/733d5ca075ca/cureus-0017-00000089820-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/001cf56cd014/cureus-0017-00000089820-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/b35b18bd1424/cureus-0017-00000089820-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/b5676c53db30/cureus-0017-00000089820-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/4b1d9a1e19e3/cureus-0017-00000089820-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/733d5ca075ca/cureus-0017-00000089820-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8006/12422397/001cf56cd014/cureus-0017-00000089820-i05.jpg

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Extragnathic Giant Cell Granuloma as a Rare Consideration for a Periorbital Mass in an Infant: A Case Report.颌骨外巨细胞肉芽肿作为婴儿眶周肿物的罕见病因：一例报告
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本文引用的文献

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Diagnosis and management of central giant cell granulomas of the jaws: a European and multicenter study.颌骨中心性巨细胞肉芽肿的诊断与治疗：一项欧洲多中心研究
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巨细胞肉芽肿的发病率、治疗方法和复发率：回顾性研究。
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Imaging Features of Craniofacial Giant Cell Granulomas: A Large Retrospective Analysis from a Tertiary Care Center.颅面部巨细胞肉芽肿的影像学特征：来自一家三级护理中心的大型回顾性分析。
AJNR Am J Neuroradiol. 2022 Aug;43(8):1190-1195. doi: 10.3174/ajnr.A7568. Epub 2022 Jul 7.
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Integrated proteomics, phosphoproteomics and metabolomics analyses reveal similarities among giant cell granulomas of the jaws with different genetic mutations.整合蛋白质组学、磷酸化蛋白质组学和代谢组学分析揭示了具有不同基因突变的颌骨巨细胞肉芽肿之间的相似性。
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Giant Cell-Rich Tumors of Bone.骨巨细胞瘤
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Towards better understanding of giant cell granulomas of the oral cavity.旨在更好地理解口腔巨细胞肉芽肿。
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