From the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.).
From the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.)
AJNR Am J Neuroradiol. 2022 Aug;43(8):1190-1195. doi: 10.3174/ajnr.A7568. Epub 2022 Jul 7.
Craniofacial giant cell granulomas are rare lesions with varied appearances on imaging. We aimed to describe the imaging features of giant cell granulomas of the craniofacial bones.
A retrospective analysis of the clinical features and imaging findings of 20 histopathology-proved cases of craniofacial giant cell granulomas, dating from 2006 to 2022, was performed.
Of the 20 cases, 10 each were seen in men and women. The epicenter of the lesions varied in location: in the maxilla in 8 patients, in the mandible in 5, in the temporal bone in 3, in the sphenoid/clivus in 3, and in the orbit in 1 patient. On the radiographs, the lesions appeared well-circumscribed, expansile, and lytic. On CT, the lesions were predominantly multiloculated, with thin septa, a soft-tissue component, and with expansion and remodeling of the underlying bone. On MR imaging, the solid component of the lesions was isointense on T1WI and hypointense on T2WI, with heterogeneous enhancement of the solid component and rim enhancement of the locules. Fluid-fluid levels were present in 3 patients.
Giant cell granulomas commonly present as locally aggressive, expansile, multiloculated lytic lesions, with solid as well as cystic areas. The solid component is typically hypointense on T2WI. Certain key imaging features of giant cell granulomas can aid the radiologist in narrowing the differential diagnosis.
颅面巨大细胞肉芽肿是一种罕见的病变，其影像学表现多样。本研究旨在描述颅面骨巨大细胞肉芽肿的影像学特征。
回顾性分析了 2006 年至 2022 年间经组织病理学证实的 20 例颅面巨大细胞肉芽肿患者的临床特征和影像学表现。
20 例患者中，男、女各 10 例。病变的中心位置各不相同：上颌骨 8 例，下颌骨 5 例，颞骨 3 例，蝶骨/斜坡 3 例，眼眶 1 例。X 线平片上，病变边界清楚，呈膨胀性、溶骨性。CT 上，病变主要为多房性，间隔薄，有软组织成分，并伴有骨的膨胀和改建。MR 成像上，病变的实性部分在 T1WI 上呈等信号，在 T2WI 上呈低信号，实性部分呈不均匀强化，房隔呈边缘强化。3 例患者可见液-液平面。
巨大细胞肉芽肿通常表现为局部侵袭性、膨胀性、多房性溶骨性病变，伴有实性和囊性区域。实性部分在 T2WI 上呈低信号。巨大细胞肉芽肿的某些关键影像学特征有助于放射科医生缩小鉴别诊断范围。
