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Late-Onset Veno-Occlusive Disease (VOD) Post Haploidentical Transplant: A Diagnostic Challenge Requiring Liver Biopsy- A Case Report.

作者信息

Trehan Mehak, Sharma Homdutt, Sengupta Abhinav, Burli Anirudh, Kumar Pradeep, Mahapatra Manoranjan

机构信息

Senior Resident, Hematology Department, All India Institute of Medical Sciences, Delhi.

Associate Professor, Hematology Department, All India Institute of Medical Sciences, Delhi.

出版信息

Mediterr J Hematol Infect Dis. 2025 Sep 1;17(1):e2025068. doi: 10.4084/MJHID.2025.068. eCollection 2025.

DOI:10.4084/MJHID.2025.068
PMID:40937313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12422249/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c271/12422249/123188aeb1da/mjhid-17-1-e2025068f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c271/12422249/123188aeb1da/mjhid-17-1-e2025068f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c271/12422249/123188aeb1da/mjhid-17-1-e2025068f1.jpg

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1
Late-Onset Veno-Occlusive Disease (VOD) Post Haploidentical Transplant: A Diagnostic Challenge Requiring Liver Biopsy- A Case Report.单倍体相合移植后迟发性肝静脉闭塞病（VOD）：一项需要肝活检的诊断挑战——病例报告
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Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease after Unmanipulated Haploidentical Hematopoietic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide: A Study on Behalf of the Spanish Hematopoietic Stem Cell Transplantation and Cellular Therapy Group (GETH).未预处理单倍体造血干细胞移植后应用环磷酰胺治疗的窦状隙阻塞综合征/静脉闭塞病：西班牙造血干细胞移植和细胞治疗组（GETH）的一项研究。
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本文引用的文献

1
Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group.成人患者肝窦阻塞综合征/静脉闭塞性疾病的预防性、先发制性和治愈性治疗：国际专家组的立场声明
Bone Marrow Transplant. 2020 Mar;55(3):485-495. doi: 10.1038/s41409-019-0705-z. Epub 2019 Oct 1.
2
Risk Factors for Development of and Progression of Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome.肝静脉闭塞病/窦状隙阻塞综合征发展和进展的风险因素。
Biol Blood Marrow Transplant. 2019 Jul;25(7):1271-1280. doi: 10.1016/j.bbmt.2019.02.018. Epub 2019 Feb 22.
3
Utility and Safety of Liver Biopsy in Patients with Undetermined Liver Blood Test Anomalies after Allogeneic Hematopoietic Stem Cell Transplantation: A Monocentric Retrospective Cohort Study.
异基因造血干细胞移植后不明原因肝血试验异常患者肝活检的效用和安全性：一项单中心回顾性队列研究。
Biol Blood Marrow Transplant. 2018 Dec;24(12):2523-2531. doi: 10.1016/j.bbmt.2018.07.037. Epub 2018 Jul 30.
4
Late-Onset Hepatic Veno-Occlusive Disease after Allografting: Report of Two Cases with Atypical Clinical Features Successfully Treated with Defibrotide.移植后迟发性肝静脉闭塞病：两例具有非典型临床特征的病例报告，使用去纤苷成功治疗
Mediterr J Hematol Infect Dis. 2018 Jan 1;10(1):e2018001. doi: 10.4084/MJHID.2018.001. eCollection 2018.
5
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.儿童患者窦状隙阻塞综合征/静脉阻塞性疾病的诊断和严重程度标准：来自欧洲血液和骨髓移植学会的新分类。
Bone Marrow Transplant. 2018 Feb;53(2):138-145. doi: 10.1038/bmt.2017.161. Epub 2017 Jul 31.
6
Phase 3 trial of defibrotide for the treatment of severe veno-occlusive disease and multi-organ failure.去纤苷治疗严重肝静脉闭塞病和多器官功能衰竭的3期试验。
Blood. 2016 Mar 31;127(13):1656-65. doi: 10.1182/blood-2015-10-676924. Epub 2016 Jan 29.
7
Hepatic Veno-Occlusive Disease after Hematopoietic Stem Cell Transplantation: Risk Factors and Stratification, Prophylaxis, and Treatment.造血干细胞移植后肝静脉闭塞病：危险因素与分层、预防及治疗
Biol Blood Marrow Transplant. 2016 Mar;22(3):400-9. doi: 10.1016/j.bbmt.2015.09.024. Epub 2015 Oct 23.
8
Sinusoidal obstruction syndrome (hepatic veno-occlusive disease).窦性阻塞综合征（肝静脉闭塞病）
J Clin Exp Hepatol. 2014 Dec;4(4):332-46. doi: 10.1016/j.jceh.2014.10.002. Epub 2014 Oct 30.
9
Hepatic veno-occlusive disease following stem cell transplantation: incidence, clinical course, and outcome.肝静脉闭塞病（VOD）继造血干细胞移植后：发病率、临床病程和结果。
Biol Blood Marrow Transplant. 2010 Feb;16(2):157-68. doi: 10.1016/j.bbmt.2009.08.024. Epub 2009 Sep 18.