exerts a carcinogenic effect on hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is associated with the highest mortality rate among various types of liver tumors. a microRNA, has been identified as a tumor suppressor in multiple cancer types, yet its function in hepatocellular carcinoma has not been investigated. This study aimed to examine the effect of on the occurrence and development of HCC and its specific molecular mechanism. Here, we evaluated the effect of on HCC proliferation by using proliferation assays and a xenograft tumor model. Flow cytometry was used to monitor the cell cycle and apoptosis of HCC cells. Reverse Transcription-Quantitative Polymerase Chain Reaction (RT-qPCR) and Western blot (WB) were used to determine the expression of each gene. Our study showed that levels decrease in HCC, and its overexpression can enhance cell proliferation and cell cycle progression while suppressing apoptosis. Examination of the gene expression profiles of MHCC9H cells with overexpression shows that cancer-promoting pathways like hypoxia and Notch signaling are upregulated. Meanwhile, overexpression inhibits tumor suppressor pathways such as apoptosis and p53 signaling. affects the cell cycle and apoptosis of HCC through the p53 pathway. Moreover, the expression of is regulated by p53 to some extent. Our findings suggest that has a tumor-promoting effect on HCC and that inhibitors may be a new therapeutic approach for HCC.