Li Yongge, Miao Xu, Jia Rui, Liu Ruikang
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China.
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China.
Front Cell Infect Microbiol. 2025 Aug 27;15:1662511. doi: 10.3389/fcimb.2025.1662511. eCollection 2025.
Poxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm. Their life cycle is closely associated with various membrane-related cellular processes. This review summarizes current findings on the complex interplay between poxviruses and autophagy, as well as the endo-lysosomal network. However, due to the large diversity of poxvirus species and the limited number of relevant studies, it remains challenging to draw definitive conclusions regarding the bidirectional regulatory relationship between poxviruses and the autophagy-lysosome system. In addition, poxviruses can serve as a promising platform for oncolytic virus development. Furthermore, we also highlight recent studies leveraging autophagy modulation to enhance the therapeutic efficacy of oncolytic poxviruses. Thus, elucidation of the interplay between poxviruses and autophagy-lysosome pathway will not only advance the understanding of virology and cell biology, but also facilitate the engineering of oncolytic poxviruses as innovative tools for cancer therapy.
痘病毒是大型双链DNA病毒，仅在细胞质中复制。它们的生命周期与各种膜相关的细胞过程密切相关。本综述总结了关于痘病毒与自噬以及内溶酶体网络之间复杂相互作用的当前研究结果。然而，由于痘病毒种类繁多且相关研究数量有限，就痘病毒与自噬 - 溶酶体系统之间的双向调节关系得出明确结论仍然具有挑战性。此外，痘病毒可作为溶瘤病毒开发的一个有前景的平台。此外，我们还强调了最近利用自噬调节来提高溶瘤痘病毒治疗效果的研究。因此，阐明痘病毒与自噬 - 溶酶体途径之间的相互作用不仅将推进对病毒学和细胞生物学的理解，还将促进溶瘤痘病毒作为癌症治疗创新工具的工程化。
