Ijaz Aiman, Ain Huma Bader Ul, Tufail Tabussam, Mariam Raima, Noreen Sana, Amjad Aniqa, Ikram Ali, Arshad Muhammad Tayyab, Abdullahi Muhammed Adem
University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan.
School of Food Science and Engineering, Yangzhou University, Yangzhou, China.
J Cachexia Sarcopenia Muscle. 2025 Oct;16(5):e70060. doi: 10.1002/jcsm.70060.
Sarcopenia is characterised by a decline in the skeletal muscle mass with increasing age. This poses many challenges to the health and independence of older individuals. New and emerging studies have focused on supplementing leucine-enriched whey protein and resistance training in older adults to mitigate the effects of sarcopenia, including significant muscle mass loss.
This study aimed to comprehensively analyse the current literature regarding the beneficial effects of leucine-enriched whey protein supplementation in older adults. This article systematically reviewed randomised controlled trials, longitudinal studies, and meta-analyses published between 2011 and 2024. The biochemical mechanisms underlying the anabolic properties of leucine, including its role in protein synthesis and mTOR signalling pathways, were explored to elucidate its potential to enhance muscle protein accretion.
Findings from the reviewed studies indicate that the combined intervention of leucine-enriched whey protein supplementation and resistance training elicits favourable outcomes regarding increased lean muscle mass, muscle strength and physical performance in older adults with sarcopenia. The potential of leucine-enriched whey protein to mitigate muscle protein breakdown is discussed along with its potential synergistic effects with resistance exercise to optimise muscle adaptation. Future research directions, including investigations of optimal dosing regimens, long-term sustainability and potential contraindications, are proposed to enhance the precision and applicability of this intervention strategy.
Leucine-enriched whey protein supplementation combined with resistance training is beneficial in addressing sarcopenia in older adults. This review consolidates the current understanding of this intervention, highlights its potential benefits and provides insights for future research and clinical applications in geriatric muscle health.
肌肉减少症的特征是随着年龄增长骨骼肌质量下降。这给老年人的健康和独立性带来了诸多挑战。新出现的研究聚焦于在老年人中补充富含亮氨酸的乳清蛋白和进行抗阻训练，以减轻肌肉减少症的影响，包括显著的肌肉质量损失。
本研究旨在全面分析当前有关补充富含亮氨酸的乳清蛋白对老年人有益作用的文献。本文系统回顾了2011年至2024年间发表的随机对照试验、纵向研究和荟萃分析。探讨了亮氨酸合成代谢特性的生化机制，包括其在蛋白质合成和mTOR信号通路中的作用，以阐明其增强肌肉蛋白质积累的潜力。
综述研究的结果表明，补充富含亮氨酸的乳清蛋白与抗阻训练相结合的干预措施，对于增加肌肉减少症老年人的瘦肌肉质量、肌肉力量和身体机能产生了有利结果。讨论了富含亮氨酸的乳清蛋白减轻肌肉蛋白质分解的潜力，以及其与抗阻运动的潜在协同作用，以优化肌肉适应性。提出了未来的研究方向，包括对最佳给药方案、长期可持续性和潜在禁忌症的研究，以提高这种干预策略的精准性和适用性。
补充富含亮氨酸的乳清蛋白并结合抗阻训练，对解决老年人的肌肉减少症有益。本综述巩固了目前对这种干预措施的认识，突出了其潜在益处，并为老年肌肉健康的未来研究和临床应用提供了见解。
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