Amasene Maria, Cadenas-Sanchez Cristina, Echeverria Iñaki, Sanz Begoña, Alonso Cristina, Tobalina Ignacio, Irazusta Jon, Labayen Idoia, Besga Ariadna
Department of Pharmacy and Food Science, University of the Basque Country UPV/EHU, 01006 Vitoria-Gasteiz, Spain.
Institute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Public University of Navarra, 31006 Pamplona, Spain.
J Clin Med. 2021 Dec 24;11(1):97. doi: 10.3390/jcm11010097.
Resistance training and protein supplementation are expected to exert the greatest effect in counteracting muscle-wasting conditions. Myokines might play a key role, but this remains to be elucidated. The aim of this study (NCT03815201) was to examine the effects of a resistance training program with post-exercise leucine-enriched protein supplementation on sarcopenia and frailty status and on the plasma myokine concentrations of post-hospitalized older adults. A total of 41 participants were included in this 12-week resistance training intervention and randomized either to the placebo group or the protein group. Sarcopenia, frailty, body composition and blood-based myokines were measured at baseline and after 12 weeks. Both groups improved in terms of physical performance ( < 0.005) and frailty ( < 0.07) following the resistance training intervention, but without any difference between groups. Myokine concentrations did not change after the intervention in either group. Changes in myostatin concentrations were associated with greater improvements in appendicular skeletal muscle mass at the end of the intervention ( < 0.05). In conclusion, the implementation of resistance training programs after hospitalization in older adults should be prioritized to combat sarcopenia and frailty immediately. The results regarding myostatin should be taken as preliminary findings.
抗阻训练和补充蛋白质有望在对抗肌肉萎缩状况方面发挥最大作用。肌动蛋白可能起关键作用，但这一点仍有待阐明。本研究（NCT03815201）的目的是检验一项抗阻训练计划联合运动后补充富含亮氨酸的蛋白质对住院后老年人的肌肉减少症、衰弱状况及血浆肌动蛋白浓度的影响。共有41名参与者纳入了这项为期12周的抗阻训练干预，并随机分为安慰剂组或蛋白质组。在基线期和12周后测量肌肉减少症、衰弱、身体成分和血液中的肌动蛋白。抗阻训练干预后，两组在身体机能（<0.005）和衰弱（<0.07）方面均有改善，但两组间无差异。干预后两组的肌动蛋白浓度均未改变。干预结束时，肌肉生长抑制素浓度的变化与附属骨骼肌质量的更大改善相关（<0.05）。总之，应优先在老年人住院后实施抗阻训练计划，以立即对抗肌肉减少症和衰弱。关于肌肉生长抑制素的结果应被视为初步发现。
