Plant antitumor agents, 21. Flavones, coumarins, and an alkaloid from Sargentia greggii.
作者信息
Meyer B N, Wall M E, Wani M C, Taylor H L
出版信息
J Nat Prod. 1985 Nov-Dec;48(6):952-6. doi: 10.1021/np50042a012.
PMID:4093779
Abstract
Investigation of the MeOH extracts of Sargentia greggii (Rutaceae) led to the isolation of two known flavones, zapotin and 5,6,2'-trimethoxyflavone, and a new flavone, 5,6,2',3',4',6'-hexamethoxyflavone (1), whose structure was established by spectral data and confirmed by total synthesis. In addition, two known coumarins, 3-(alpha,alpha-dimethylallyl) herniarin and seselin, and a new coumarin, O-geranylosthenol (3), have been isolated from this plant. The structure of 3 was deduced from spectral data. Although the crude extracts displayed KB activity, none of the crystalline compounds were significantly active.
摘要
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