年龄和体重指数对健康人体组胺H3受体可用性的影响。
Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans.
作者信息
Yang Yanghong, Ibrahim Waleed, Gravel Paul, Pittman Brian, Hoye Jocelyn, Cool Ryan, Sadabad Faranak Ebrahimian, Zheng Ming-Qiang, Pittenger Christopher, Gallezot Jean-Dominique, Carson Richard E, Huang Henry, Radhakrishnan Rajiv, Matuskey David
机构信息
Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Department of Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
出版信息
Mol Imaging Biol. 2025 Sep 12. doi: 10.1007/s11307-025-02047-8.
PURPOSE
To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [C]GSK189254 positron emission tomography (PET) imaging.
PROCEDURE
Twenty-four healthy individuals (2 females, 22 males; age range 20-47 years) were scanned with [C]GSK189254 with High-Resolution Research Tomograph (HRRT) or HR plus scanner. Regional V (volume of distribution) values were computed using the two-tissue compartment model. The correlation between V and age, BMI were examined, adjusting for relevant potential confounding effects of age or gender and injected mass.
RESULTS
H3R availability (V) was correlated with age but not BMI. V displayed a negative correlation with age in the anterior cingulate cortex (r = -0.61, p = 0.004), frontal cortex (r = -0.50, p = 0.020), olfactory cortex (r = -0.50, p = 0.022), parietal cortex (r = -0.58, p = 0.006), cerebellum cortex (r = -0.53, p = 0.013), insula (r = -0.48, p = 0.027), putamen (r = -0.46, p = 0.034), thalamus (r = -0.45, p = 0.038), and hippocampus (r = 0.45, p = 0.039).
CONCLUSION
This in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.
目的
使用体内[C]GSK189254正电子发射断层扫描（PET）成像评估健康人体内H3R可用性随年龄和体重指数（BMI）的变化。
程序
对24名健康个体（2名女性，22名男性；年龄范围20 - 47岁）使用[C]GSK189254进行高分辨率研究断层扫描仪（HRRT）或HR plus扫描仪扫描。使用双组织室模型计算区域分布容积（V）值。检查V与年龄、BMI之间的相关性，并对年龄或性别以及注射量的相关潜在混杂效应进行校正。
结果
H3R可用性（V）与年龄相关，但与BMI无关。在前扣带回皮质（r = -0.61，p = 0.004）、额叶皮质（r = -0.50，p = 0.020）、嗅觉皮质（r = -0.50，p = 0.022）、顶叶皮质（r = -0.58，p = 0.006）、小脑皮质（r = -0.53，p = 0.013）、岛叶（r = -0.48，p = 0.027）、壳核（r = -0.46，p = 0.034）、丘脑（r = -0.45，p = 0.038）和海马体（r = 0.45，p = 0.039）中，V与年龄呈负相关。
结论
这项体内H3R研究发现，大多数皮质和皮质下区域的H3R可用性随年龄显著下降。
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