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Protective Role of Luteolin against Endothelial Ferroptosis: Linking Antioxidant Pathways To Vascular Health.

作者信息

Garelnabi Mahdi

机构信息

Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA, USA.

Department of Biomedical and Nutritional Sciences, Zuckerberg College of Health Sciences, University of Massachusetts, 3 Solomont Way, Suite 4, Lowell, MA, 01854, USA.

出版信息

Cell Biochem Biophys. 2025 Sep 12. doi: 10.1007/s12013-025-01892-2.

DOI:10.1007/s12013-025-01892-2
PMID:40938485
Abstract
摘要

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本文引用的文献

1
Targeting Ferroptosis in Tumors: Novel Marine-Derived Compounds as Regulators of Lipid Peroxidation and GPX4 Signaling.靶向肿瘤中的铁死亡：新型海洋来源化合物作为脂质过氧化和谷胱甘肽过氧化物酶4信号通路的调节剂
Mar Drugs. 2025 Jun 19;23(6):258. doi: 10.3390/md23060258.
2
The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells.PGC-1α在氧化低密度脂蛋白诱导的血管内皮细胞铁死亡中的作用及机制
Atheroscler Plus. 2025 Jun 6;61:1-11. doi: 10.1016/j.athplu.2025.05.002. eCollection 2025 Sep.
3
Protective Effects of Panax notoginseng Saponins on Cerebral Ischemia/Reperfusion Injury: Insights Into SIRT1/NRF2/HO-1 Pathway Activation.
三七总皂苷对脑缺血/再灌注损伤的保护作用：对SIRT1/NRF2/HO-1信号通路激活的见解
Physiol Res. 2025 Apr 30;74(2):313-326.
4
Mechanism of a Novel Complex: Zinc Oxide Nanoparticles-Luteolin to Promote Ferroptosis in Human Acute Myeloid Leukemia Cells in Vitro.一种新型复合物的作用机制：氧化锌纳米颗粒-木犀草素体外促进人急性髓系白血病细胞铁死亡
Int J Nanomedicine. 2025 Apr 2;20:4035-4050. doi: 10.2147/IJN.S509007. eCollection 2025.
5
Luteolin Inhibits Dexamethasone-Induced Osteoporosis by Autophagy Activation Through miR-125b-5p/SIRT3/AMPK/mTOR Axis, an In Vitro and In Vivo Study.木犀草素通过miR-125b-5p/SIRT3/AMPK/mTOR轴激活自噬抑制地塞米松诱导的骨质疏松症：一项体外和体内研究
Food Sci Nutr. 2025 Mar 17;13(3):e70071. doi: 10.1002/fsn3.70071. eCollection 2025 Mar.
6
Luteolin Alleviates Inflammation Induced by in Bovine Mammary Epithelial Cells by Attenuating NF-κB and MAPK Activation.木犀草素通过减弱NF-κB和MAPK激活减轻大肠杆菌诱导的牛乳腺上皮细胞炎症。
Vet Sci. 2025 Jan 27;12(2):96. doi: 10.3390/vetsci12020096.
7
Resveratrol attenuates cyclophosphamide-induced hepatic apoptosis in association with the inhibition of oxidative stress and inflammation in a rat model of acute liver injury.白藜芦醇可减轻环磷酰胺诱导的肝脏细胞凋亡，同时抑制急性肝损伤大鼠模型中的氧化应激和炎症反应。
Tissue Cell. 2025 Apr;93:102728. doi: 10.1016/j.tice.2025.102728. Epub 2025 Jan 7.
8
Luteolin attenuates CCl4-induced hepatic injury by inhibiting ferroptosis via SLC7A11.木犀草素通过抑制 SLC7A11 抑制铁死亡来减轻 CCl4 诱导的肝损伤。
BMC Complement Med Ther. 2024 May 16;24(1):193. doi: 10.1186/s12906-024-04486-2.
9
Luteolin exhibits synergistic therapeutic efficacy with erastin to induce ferroptosis in colon cancer cells through the HIC1-mediated inhibition of GPX4 expression.木犀草素通过抑制 HIC1 介导的 GPX4 表达与 erastin 协同发挥治疗作用，诱导结肠癌细胞发生铁死亡。
Free Radic Biol Med. 2023 Nov 1;208:530-544. doi: 10.1016/j.freeradbiomed.2023.09.014. Epub 2023 Sep 17.
10
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.依达拉奉通过 Sirt1/Nrf2/HO-1/Gpx4 通路改善抑郁和焦虑样行为。
J Neuroinflammation. 2022 Feb 7;19(1):41. doi: 10.1186/s12974-022-02400-6.