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青少年和青年阿片类药物使用障碍及过量用药的预防与管理

Prevention and Management of Opioid use Disorder and Overdose in Adolescents and Young Adults.

作者信息

Welsh Justine W, Krishnan Snehaa D, Terranella Andrew

机构信息

Emory University School of Medicine, Atlanta, GA, USA.

University of Arizona School of Medicine, Tucson, AZ, USA.

出版信息

Curr Psychiatry Rep. 2025 Sep 12. doi: 10.1007/s11920-025-01638-0.

Abstract

PURPOSE

Despite more recent declines in opioid overdose deaths, opioid use among adolescents and young adults (AYA) continues to be a significant public health crisis in the U.S., contributing to various adverse health outcomes. We summarized peer-reviewed literature on the prevalence, risk factors, treatment options, and barriers to evidence-based care for AYA with opioid misuse and opioid use disorder (OUD).

RECENT FINDINGS

Despite the significant need, treatment access for OUD among AYA is low, with limited utilization of evidence-based practices including medications for OUD (MOUD). Primary barriers to effective treatment include inadequate healthcare provider training, a shortage of specialized facilities, prevalent stigma towards treatment, and prohibitive costs. Furthermore, greater naloxone distribution is necessary to reduce overdose deaths in this population. Comprehensive efforts to enhance MOUD accessibility, integrate behavioral interventions, reduce stigma, and support ongoing research into effective AYA-specific strategies are needed to address this national crisis.

摘要

目的

尽管近期阿片类药物过量死亡人数有所下降,但美国青少年和青年(AYA)中的阿片类药物使用仍是一个重大的公共卫生危机,导致各种不良健康后果。我们总结了经同行评审的关于青少年和青年阿片类药物滥用及阿片类药物使用障碍(OUD)的患病率、风险因素、治疗选择以及循证护理障碍的文献。

最新发现

尽管有巨大需求,但青少年和青年中阿片类药物使用障碍的治疗可及性较低,包括阿片类药物使用障碍药物(MOUD)在内的循证实践的利用率有限。有效治疗的主要障碍包括医疗保健提供者培训不足、专业设施短缺、对治疗普遍存在的污名化以及高昂的成本。此外,需要更广泛地分发纳洛酮以减少该人群中的过量死亡。需要做出全面努力,以提高MOUD的可及性、整合行为干预措施、减少污名化,并支持对有效的针对青少年和青年的特定策略进行持续研究,以应对这一全国性危机。

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