Zhao Liang, Guo Zhenfeng, Ji Xiaodong, Sun Fengyuan, Xia Shuang
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.
Tianjin Beichen Hospital, Tianjin, China.
PLoS One. 2025 Sep 12;20(9):e0332199. doi: 10.1371/journal.pone.0332199. eCollection 2025.
This study aimed to compare the differences in the quantitative parameters of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) across various types of orbital space-occupying lesions and to explore the diagnostic efficacy of DCE-MRI in the diagnosis of malignant orbital tumors.Meanwhile,to compare the differences in the quantitative parameters of DCE-MRI across vascular malformations, benign tumors, and malignant orbital lesions,and to explore the diagnostic efficacy of DCE-MRI introducing a novel grouping strategy that distinguishes vascular malformations from solid tumors.
In this retrospective case series study, patients were classified into three groups: vascular malformations, benign lesions, and malignant lesions. We analyzed the differences in the quantitative parameters and time-intensity curve (TIC) profiles among the three groups. The diagnostic efficacy of the quantitative parameters in the diagnosis of orbital malignant lesions was analyzed using receiver operating characteristic (ROC) curves.
The differences in TIC compositions among the three groups were statistically significant (P < 0.05).The differences in volume transfer constant(Ktrans) value,rate constant(Kep) value,and area under curve(iAUC) among the three groups exhibited statistically significant differences (P < 0.05). All three diagnostic parameters(Ktrans, Kep, and iAUC) demonstrated effectiveness in diagnosing malignant lesions. The area under the ROC curve values for Ktrans, Kep, and iAUC were 0.759, 0.764, and 0.752, respectively, indicating adequate diagnostic value.
The composition ratios of the TIC for vascular malformations, benign lesions, and malignant lesions differed considerably. Ktrans, Kep, and iAUC can serve as valuable references for the differential diagnosis of orbital space-occupying lesions.
本研究旨在比较不同类型眼眶占位性病变在定量动态对比增强磁共振成像（DCE-MRI）中的定量参数差异，探讨DCE-MRI对眼眶恶性肿瘤的诊断效能。同时，比较血管畸形、良性肿瘤和眼眶恶性病变在DCE-MRI定量参数上的差异，探索一种将血管畸形与实体瘤区分开来的新型分组策略下DCE-MRI的诊断效能。
在这项回顾性病例系列研究中，患者被分为三组：血管畸形、良性病变和恶性病变。我们分析了三组之间定量参数和时间-强度曲线（TIC）特征的差异。使用受试者工作特征（ROC）曲线分析定量参数对眼眶恶性病变的诊断效能。
三组之间TIC组成的差异具有统计学意义（P < 0.05）。三组之间的容积转移常数（Ktrans）值、速率常数（Kep）值和曲线下面积（iAUC）存在统计学显著差异（P < 0.05）。所有三个诊断参数（Ktrans、Kep和iAUC）在诊断恶性病变方面均显示出有效性。Ktrans、Kep和iAUC的ROC曲线下面积值分别为0.759、0.764和0.752，表明具有足够的诊断价值。
血管畸形、良性病变和恶性病变的TIC组成比例有很大差异。Ktrans、Kep和iAUC可作为眼眶占位性病变鉴别诊断的有价值参考。
