Baker D G, Schumacher H R, Wolf G L
J Rheumatol. 1985 Dec;12(6):1062-5.
In vitro studies were performed on joint tissues and fluid to evaluate the potential for nuclear magnetic resonance (NMR) in the study of joint disease. Values for spin lattice relaxation times, spin-spin relaxation times and mobile proton content were obtained on 51 consecutive whole synovial fluids (SF). Correlations were sought between NMR values and white blood counts, protein content, calcium, phosphorus, and diagnosis. Only a very weak correlation (0.444) was noted with total SF protein. Albumin added in vitro did produce good correlation (0.975). NMR values were not altered by the addition of monosodium urate, of calcium pyrophosphate, or hydroxyapatite crystals. In vitro measurements of dissected canine articular tissue showed differences in NMR between the different joint components and between inflamed and noninflamed tissues. Our findings suggest that estimation of the amount of inflammation by NMR values is not possible at this time, but with refinements of techniques, magnetic resonance imaging may provide superb images of articular soft tissue structures.
对关节组织和关节液进行了体外研究，以评估核磁共振（NMR）在关节疾病研究中的潜力。在51份连续的全滑膜液（SF）样本上获取了自旋晶格弛豫时间、自旋-自旋弛豫时间和可移动质子含量的值。研究了NMR值与白细胞计数、蛋白质含量、钙、磷以及诊断结果之间的相关性。仅发现与总SF蛋白有非常弱的相关性（0.444）。体外添加白蛋白确实产生了良好的相关性（0.975）。添加尿酸钠、焦磷酸钙或羟基磷灰石晶体不会改变NMR值。对解剖后的犬关节组织进行的体外测量显示，不同关节成分之间以及炎症组织与非炎症组织之间的NMR存在差异。我们的研究结果表明，目前通过NMR值来估计炎症程度是不可能的，但随着技术的改进，磁共振成像可能会提供出色的关节软组织结构图像。
