Peterson Daniel S, Johansson Linda, Westerlind Björn, Lopes de Oliveira Thaís, Finkel Deborah
Institute of Gerontology, School of Health and Welfare, Jönköping University, Jönköping, Sweden.
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Sci Rep. 2025 Sep 12;15(1):32508. doi: 10.1038/s41598-025-17752-1.
Temporal aspects of falls are not well characterized in people with Parkinson's disease (PD), particularly those later in life. The purpose of the current study is to characterize the timing (across day and year) of falls in people with probable PD compared to non-PD peers. Swedish registries were used to identify 441 people (mean age, 83.7 years, range = [59.0-100.0]) with one or more prospectively registered falls over the course of approximately 2.5 years. Of these participants, 40 were prescribed drugs of the class N04 "Anti-Parkinson Drugs". Of these 40, 30 were prescribed dopamine or dopamine derivatives, suggesting presence of PD, and 10 were prescribed "other PD-related medications". Given the unclear nature of these 10 participants, they were excluded from all analyses. Chi-squared tests and Generalized Estimating Equations were used to assess the time of day and year of falls in people with probable PD (n = 30) and non-PD (n = 401) accounting for covariates (age, gender, number of prescription medications). There was a statistically-significant effect of PD-group on fall time of day (accounting for gender, age, & number of prescription medications), such that Swedish residents with probable PD fell less often in the evening than the day (p = 0.015, OR = 0.61). Across the whole sample, female participants fell less frequently at night than the day (p = 0.032, OR = 0.73). People with probable PD fell more frequently in the spring months than other seasons (×2 = 32.1, p < 0.001). The finding that people with probable PD exhibit more falls during the day than night is consistent with previous work and extends knowledge to show a similar result in older, more frail people with PD. Characterizing the temporal nature of falls in people with PD can provide additional context to other fall circumstances, thus improving our ability to treat and predict falls in this group.
帕金森病（PD）患者跌倒的时间特征尚未得到很好的描述，尤其是老年患者。本研究的目的是描述可能患有PD的患者与非PD同龄人相比跌倒的时间（全天和全年）。瑞典登记处用于识别441名（平均年龄83.7岁，范围=[59.0 - 100.0]）在大约2.5年的时间里有一次或多次前瞻性登记跌倒的人。在这些参与者中，40人被开具了N04类“抗帕金森病药物”。在这40人中，30人被开具了多巴胺或多巴胺衍生物，表明存在PD，10人被开具了“其他与PD相关的药物”。鉴于这10名参与者情况不明确，他们被排除在所有分析之外。使用卡方检验和广义估计方程来评估可能患有PD的患者（n = 30）和非PD患者（n = 401）跌倒的时间（考虑协变量：年龄、性别、处方药数量）。PD组对跌倒的日间时间有统计学显著影响（考虑性别、年龄和处方药数量），因此可能患有PD的瑞典居民晚上跌倒的频率低于白天（p = 0.015，OR = 0.61）。在整个样本中，女性参与者夜间跌倒的频率低于白天（p = 0.032，OR = 0.73）。可能患有PD的人在春季跌倒的频率高于其他季节（χ2 = 32.1，p < 0.001）。可能患有PD的人白天跌倒比晚上多这一发现与之前的研究一致，并将知识扩展到表明在年龄更大、身体更虚弱的PD患者中也有类似结果。描述PD患者跌倒的时间特征可以为其他跌倒情况提供更多背景信息，从而提高我们治疗和预测该群体跌倒的能力。
