Wu Lei, Li Shiyu, Tang Yilin, Liang Xiaoniu, Xu Zhiheng, Hu Tianyu, Liu Xiaoli, Cai Miao, Liu Xuedong
Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology, Guangzhou, China.
State Key Laboratory of Medical Neurobiology, Department of Neurology, Huashan Hospital, National Research Center for Aging and Medicine and National Center for Neurological Disorders, Fudan University, Shanghai, China.
Front Neurol. 2023 Jan 4;13:1035721. doi: 10.3389/fneur.2022.1035721. eCollection 2022.
Although the seasonal variation of motor and non-motor symptoms in Parkinson's disease (PD) has been reported, the association between seasonal change and quality of life in patients with Parkinson's disease remains to be explored.
We recruited 1,036 patients with PD in this cross-sectional retrospective study. The patients were divided into four groups based on their date of assessment, according to the classical four seasons: group 1: March to May ( = 241); group 2: June to August ( = 259); group 3: September to November( = 273); group 4: December to February ( = 263). The 39-item Parkinson's Disease Questionnaire (PDQ-39) and other clinical evaluation scales for motor and non-motor symptoms were administered. The determinants of the quality of life (QoL) were analyzed by multiple stepwise regression analyses.
A significant difference in PDQ-39 was found between group 1 (spring months) and group 3 (autumn months) after correction ( = 0.002). The Unified Parkinson's Disease Rating Scale part III (UPDRS-III) score was higher in group 1 (spring months) than in group 3 (the autumn months) ( = 0.033). The most severe determinant of QoL was the UPDRS-III score in group 1 and the Geriatric Depression Scale (GDS) score in groups 2, 3, and 4.
The current study reported seasonal fluctuation of QoL in patients with PD, with higher scores during the spring months and lower scores in the autumn months. Since the determinants for QoL also vary by season, clinicians might need to focus on specific factors across seasons before initiating therapy.
虽然已有报道帕金森病（PD）患者运动和非运动症状存在季节性变化，但帕金森病患者季节性变化与生活质量之间的关联仍有待探索。
在这项横断面回顾性研究中，我们招募了1036例帕金森病患者。根据评估日期，按照经典的四季将患者分为四组：第1组：3月至5月（n = 241）；第2组：6月至8月（n = 259）；第3组：9月至11月（n = 273）；第4组：12月至2月（n = 263）。采用39项帕金森病问卷（PDQ - 39）以及其他运动和非运动症状的临床评估量表。通过多元逐步回归分析来分析生活质量（QoL）的决定因素。
校正后发现第1组（春季月份）和第3组（秋季月份）在PDQ - 39方面存在显著差异（P = 0.002）。第1组（春季月份）的统一帕金森病评定量表第三部分（UPDRS - III）得分高于第3组（秋季月份）（P = 0.033）。生活质量最严重的决定因素在第1组是UPDRS - III得分，在第2、3和4组是老年抑郁量表（GDS）得分。
本研究报告了帕金森病患者生活质量的季节性波动，春季月份得分较高，秋季月份得分较低。由于生活质量的决定因素也随季节变化，临床医生在开始治疗前可能需要关注不同季节的特定因素。
