中枢诱导的对牛磺酸的血管减压和交感神经反应。

Centrally induced vasodepressor and sympathetic nerve responses to taurine.

作者信息

Inoue A, Takahashi H, Lee L C, Iyoda I, Sasaki S, Okajima H, Takeda K, Yoshimura M, Nakagawa M, Ijichi H

出版信息

Jpn Circ J. 1985 Nov;49(11):1180-4. doi: 10.1253/jcj.49.1180.

DOI:10.1253/jcj.49.1180

Abstract

The effects of taurine on central cardiovascular regulation were investigated by intracerebroventricular (ICV) injection of taurine in urethane-anesthetized rats. Blood pressure fell gradually to attain the maximum level at 10 to 15 min after the injection of 50 micrograms taurine and returned to the basal level 20 min later. After injecting 200 micrograms of taurine, blood pressure began to fall within 30 seconds and attained the maximum level at 2 to 5 min and did not return to the basal level by 20 min. Both heart rate and abdominal sympathetic nerve activity decreased as the blood pressure fell, However, the similar amount of taurine injected intravenously did not affect the blood pressure, the heart rate or the abdominal sympathetic nerve activity. These results suggest that taurine causes the central nervous system to lower the blood pressure by decreasing the sympathetic nerve outflow.

摘要

通过向氨基甲酸乙酯麻醉的大鼠脑室内注射牛磺酸，研究了牛磺酸对中枢心血管调节的影响。注射50微克牛磺酸后，血压逐渐下降，在10至15分钟时达到最高水平，20分钟后恢复到基础水平。注射200微克牛磺酸后，血压在30秒内开始下降，在2至5分钟时达到最高水平，20分钟时未恢复到基础水平。随着血压下降，心率和腹部交感神经活动均降低。然而，静脉注射相同剂量的牛磺酸对血压、心率或腹部交感神经活动没有影响。这些结果表明，牛磺酸通过减少交感神经传出冲动，使中枢神经系统降低血压。