Yee Pak On Patrick, Tsui Ka Chun, Fung Man Lung, Heng Boon Chin, Kocabicak Ersoy, Jahanshahi Ali, Temel Yasin, Blokland Arjan, Aquili Luca, Kalueff Allan, Wong Kah Hui, Lim Lee Wei
DrLim Neuromodulation Lab, Department of Biosciences and Bioinformatics, School of Science, Xi'an Jiaotong-Liverpool University, Suzhou 215123, China.
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong 999077, China.
Cells. 2025 Aug 27;14(17):1327. doi: 10.3390/cells14171327.
Transcutaneous auricular vagus nerve stimulation (taVNS), an emerging noninvasive neuromodulation technique, has shown promise for improving memory. A better understanding of the epigenetic mechanisms underlying the effects of taVNS would inform the molecular outcomes essential for memory and cognition. In this review, we synthesize the current literature on the neurophysiological and biochemical basis of taVNS. Next, we explore how DNA methylation regulators (e.g., DNA methyltransferase 3a) and readers (e.g., methyl-CpG binding protein 2) differentially regulate memory, and how their activity and expression can be regulated by neuronal activity. Finally, we describe the potential involvement of DNA methylation in mediating the memory regulatory effects of taVNS and discuss possible directions for future studies.
经皮耳迷走神经刺激（taVNS）是一种新兴的非侵入性神经调节技术，已显示出改善记忆的潜力。更好地理解taVNS作用背后的表观遗传机制将为记忆和认知所必需的分子结果提供信息。在本综述中，我们综合了当前关于taVNS神经生理学和生物化学基础的文献。接下来，我们探讨DNA甲基化调节因子（如DNA甲基转移酶3a）和读取器（如甲基化CpG结合蛋白2）如何差异调节记忆，以及它们的活性和表达如何受神经元活动调节。最后，我们描述了DNA甲基化在介导taVNS记忆调节作用中的潜在参与，并讨论了未来研究的可能方向。
