口腔微生物群与头颈癌：一篇叙述性综述。
The Oral Microbiome and Head and Neck Cancer: A Narrative Review.
作者信息
Golusińska-Kardach Ewelina, Yadav Hariom, Jain Shalini, Masternak Michal M, Golusiński Wojciech
机构信息
Department of Oral Surgery Periodontology and Oral Mucosa Diseases, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
USF Center for Microbiome Research, Microbiomes Institute, College of Medicine, University of South Florida Morsani, Tampa, FL 33612, USA.
出版信息
Cancers (Basel). 2025 Aug 23;17(17):2736. doi: 10.3390/cancers17172736.
In recent years, a growing body of evidence points to a link between alterations in the oral microbiome and the development and progression of head and neck cancer (HNC). At present, however, this highly complex relationship is only partially understood. In this context, there is a clear need to characterise and differentiate microbial profiles in patients with and without HNC to identify risk factors, prognostic biomarkers, and potential therapeutic targets. In the present narrative review, we synthesize the current evidence on the role of oral dysbiosis in HNC, with a particular focus on potential biomarkers and novel treatment and prevention strategies.
近年来，越来越多的证据表明口腔微生物群的改变与头颈癌（HNC）的发生和发展之间存在联系。然而，目前这种高度复杂的关系仅得到部分理解。在此背景下，明确需要对有或没有HNC的患者的微生物谱进行表征和区分，以识别风险因素、预后生物标志物和潜在的治疗靶点。在本叙述性综述中，我们综合了目前关于口腔生态失调在HNC中的作用的证据，特别关注潜在的生物标志物以及新的治疗和预防策略。
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