Yamamoto Shinji, Yoshida Nobukiyo, Sakurai Noriko, Okada Yukinori, Satoh Masayuki, Takeshita Koji, Nakai Motoki, Abe Koichiro, Yoshimura Mana, Saito Kazuhiro
Department of Radiological Technology, JCHO Tokyo Yamate Medical Center, Shinjuku 169-0073, Japan.
Department of Radiological Technology, Faculty of Medical Technology, Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Diagnostics (Basel). 2025 Aug 22;15(17):2125. doi: 10.3390/diagnostics15172125.
Cerebral perfusion single-photon emission computed tomography (SPECT) is a nuclear medicine imaging technique that uses radiopharmaceuticals that selectively accumulate in the brain. However, cerebral perfusion SPECT is typically interpreted through visual assessment, making the results susceptible to observer subjectivity and varying levels of experience. The easy -score Imaging System (eZIS) is a software that quantitatively analyzes cerebral perfusion SPECT images obtained using 99mTc-ECD by comparing them with a normal database and applying -scores for quantification. The eZIS received regulatory approval in January 2015 and is currently used as an auxiliary tool for clinical diagnosis. The eZIS aids in diagnosing Alzheimer's disease by quantifying the degree of cerebral blood flow reduction in the posterior cingulate gyrus, precuneus, and parietal lobe, which are characteristic regions affected by the disease. Additionally, it can assist in diagnosing Lewy body dementia by evaluating the "cingulate island sign," a characteristic finding in which cerebral blood flow in the posterior cingulate gyrus and precuneus is relatively preserved compared with that in the occipital lobe. eZIS is thus extremely useful for dementia diagnosis.
脑灌注单光子发射计算机断层扫描（SPECT）是一种核医学成像技术，它使用选择性积聚在大脑中的放射性药物。然而，脑灌注SPECT通常通过视觉评估进行解读，这使得结果容易受到观察者主观性和不同经验水平的影响。简易评分成像系统（eZIS）是一款软件，它通过将使用99mTc-ECD获得的脑灌注SPECT图像与正常数据库进行比较并应用评分进行量化分析。eZIS于2015年1月获得监管批准，目前用作临床诊断的辅助工具。eZIS通过量化后扣带回、楔前叶和顶叶中脑血流量减少的程度来辅助诊断阿尔茨海默病，这些区域是受该疾病影响的特征性区域。此外，它可以通过评估“扣带回岛征”来辅助诊断路易体痴呆，“扣带回岛征”是一种特征性表现，即后扣带回和楔前叶的脑血流量与枕叶相比相对保留。因此，eZIS对痴呆诊断极为有用。
