Saito K, Honda S, Egawa M, Tobe A
Jpn J Pharmacol. 1985 Nov;39(3):410-4. doi: 10.1254/jjp.39.410.
Bifemelane hydrochloride (MCI-2016) increased high K+-evoked acetylcholine (ACh) release from cortical and hippocampal slices of rats. The increasing effect of MCI-2016 was abolished in the absence of Ca ion and by pretreatment of reserpine (2.5 mg/kg, i.p.). These results suggest that monoaminergic neurons may be related to the enhancement of ACh release by MCI-2016. High K+-evoked ACh release from cortical slices was significantly decreased during aging. The decrease in ACh release was ameliorated by pretreatment of MCI-2016 (30 mg/kg, i.p.).
盐酸双苯美伦（MCI - 2016）可增加高钾诱发的大鼠皮层和海马切片中乙酰胆碱（ACh）的释放。在无钙离子存在以及经利血平（2.5 mg/kg，腹腔注射）预处理后，MCI - 2016的增加作用消失。这些结果表明单胺能神经元可能与MCI - 2016增强ACh释放有关。衰老过程中，高钾诱发的皮层切片中ACh释放显著减少。经MCI - 2016（30 mg/kg，腹腔注射）预处理后，ACh释放的减少得到改善。
