Saito K, Honda S, Egawa M, Tobe A
Jpn J Pharmacol. 1985 Nov;39(3):406-9. doi: 10.1254/jjp.39.406.
Effects of bifemelane hydrochloride (MCI-2016) on acetylcholine (ACh) and norepinephrine (NE) release from cortical slices of bilaterally carotid-artery-ligated Mongolian gerbils were examined. ACh and NE release from cortical slices of Mongolian gerbils were increased 1 hr after the ligation of bilateral carotid arteries. Pretreatment of MCI-2016 (25 mg/kg, i.p.) attenuated the increase in the release of both neurotransmitters. These effects may participate in the protective effect of MCI-2016 on cerebral ischemia in Mongolian gerbils.
研究了盐酸比芬美兰（MCI - 2016）对双侧颈动脉结扎的蒙古沙鼠皮质切片中乙酰胆碱（ACh）和去甲肾上腺素（NE）释放的影响。双侧颈动脉结扎1小时后，蒙古沙鼠皮质切片中ACh和NE的释放增加。MCI - 2016（25毫克/千克，腹腔注射）预处理减弱了两种神经递质释放的增加。这些作用可能参与了MCI - 2016对蒙古沙鼠脑缺血的保护作用。
