Bubnova Alexandra S, Vorobyeva Daria V, Godovikov Ivan A, Philippova Anna N, Gribanov Pavel S, Antoshkina Evgenia P, Osipov Sergey N
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28/1 Vavilova Str., 119334 Moscow, Russia.
Molecules. 2025 Sep 4;30(17):3623. doi: 10.3390/molecules30173623.
An efficient access to the novel representatives of α,α-disubstituted α-amino acids with 1,3-enyne unit located at their side chain has been elaborated. The method is based on Pd(II)-catalyzed hydroalkynylation of α-allenyl-α-dimethylamino esters with terminal acetylenes. The developed strategy is the first example of the metal-catalyzed allene-alkyne coupling to provide a convenient route to new unsaturated α-amino acid derivatives in good yields and high selectivity.
已详细阐述了一种有效合成新型α,α-二取代α-氨基酸的方法，这些氨基酸的侧链带有1,3-烯炔单元。该方法基于钯（II）催化的α-烯丙基-α-二甲基氨基酯与末端乙炔的氢炔基化反应。所开发的策略是金属催化的丙二烯-炔烃偶联反应的首个实例，为高产率和高选择性地制备新型不饱和α-氨基酸衍生物提供了一条便捷途径。
