Rodriguez Oscar T, Diaz Luis E, Valero Manuel F
Energy, Materials and Environment Group, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Master Program in Design and Management Process, Faculty of Engineering, Universidad de La Sabana, Chía 140013, Colombia.
Polymers (Basel). 2025 Aug 31;17(17):2383. doi: 10.3390/polym17172383.
Methicillin-resistant is a problematic pathogen due to its high-risk infections and resistance mechanisms. To fight against this bacterium, novel antimicrobial sources and new delivery systems must be developed. Antimicrobial polyurethanes for developing biomaterials can function as preventive strategies. In this study, we explore the synthesis of partially renewable polyurethanes as biomaterial carriers of novel antimicrobials. An antibacterial extract from a sp. strain and its inclusion complexes with β-cyclodextrin, used as an additional protective approach, were incorporated into castor oil-based polyurethane films through bulk or surface loading. The inclusion complexes were characterized to confirm host-guest interactions. The films were characterized by FTIR, XRD spectra, surface SEM images, hydrophilicity, thermal stability, and mechanical performance. FTIR suggested successful polyurethane synthesis. The polymers were semicrystalline and thermally stable until 260 °C, and Tg ranged between -16.9 and -9 °C. Bulk modification decreased the mechanical performance of the films. Surface modification promoted good antibacterial performance but cytotoxic potential against HDFa cells. However, PU active films showed favorable properties and hemocompatibility, making them a promising alternative for applications such as short-term dressings, serving as an antimicrobial delivery system and a preventive strategy against methicillin-resistant .
耐甲氧西林菌是一种有问题的病原体，因其具有高风险感染和耐药机制。为了对抗这种细菌，必须开发新型抗菌源和新的给药系统。用于开发生物材料的抗菌聚氨酯可作为预防策略。在本研究中，我们探索了部分可再生聚氨酯作为新型抗菌剂生物材料载体的合成。将来自某菌株的抗菌提取物及其与β-环糊精的包合物作为一种额外的保护方法，通过本体或表面负载掺入蓖麻油基聚氨酯薄膜中。对包合物进行表征以确认主客体相互作用。通过傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）光谱、表面扫描电子显微镜（SEM）图像、亲水性、热稳定性和力学性能对薄膜进行表征。FTIR表明成功合成了聚氨酯。聚合物为半结晶态，在260℃之前具有热稳定性，玻璃化转变温度（Tg）在-16.9至-9℃之间。本体改性降低了薄膜的力学性能。表面改性促进了良好的抗菌性能，但对人皮肤成纤维细胞（HDFa）具有细胞毒性潜力。然而，聚氨酯活性薄膜表现出良好的性能和血液相容性，使其成为短期敷料等应用的有前途的替代品，可作为抗菌给药系统和针对耐甲氧西林菌的预防策略。
