Zhang Heng, Yang Yiping, Yang Shengchao, Qin Yuchang, Lv Xuan, Cui Lin, Jia Wei, Liu Zhiyong
Key Laboratory of Green Process for Chemical Engineering, Key Laboratory for Chemical Materials of Xinjiang Uygur Autonomous Region, Engineering Center for Chemical Materials of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China.
School of Medical Science, Shihezi University, Shihezi 832003, China.
Materials (Basel). 2025 Sep 5;18(17):4165. doi: 10.3390/ma18174165.
The impact of encapsulating gemcitabine (GEM) into nanoparticles on its delivery remains underexplored, with the potential benefits of targeted drug delivery and stimuli-responsive release yet to be fully clarified. Herein, we designed a near-infrared (NIR) light-responsive polymeric nanoparticle, ZnPc@P(PEG-CMA-TKGEM), which integrates reactive oxygen species (ROS) generation and cell imaging capabilities. The self-assembled polymeric micelles exhibit a hydrodynamic size of ~134 nm. Under NIR irradiation, the cumulative drug release rate reaches 51% within 48 h, which is three times higher than that of the non-irradiated control group. In cytotoxicity assays, the cell viability of the NIR-irradiated drug-loaded group is approximately 17%, while that of the NIR-irradiated blank group (without drug loading) remains above 80%. These results confirm that the nanocarriers successfully deliver GEM to target cells and achieve controlled drug release via NIR stimulation.
将吉西他滨（GEM）封装到纳米颗粒中对其递送的影响仍未得到充分研究，靶向药物递送和刺激响应释放的潜在益处尚未完全阐明。在此，我们设计了一种近红外（NIR）光响应聚合物纳米颗粒ZnPc@P(PEG-CMA-TKGEM)，它整合了活性氧（ROS）生成和细胞成像能力。自组装的聚合物胶束的流体动力学尺寸约为134nm。在近红外照射下，48小时内累积药物释放率达到51%，这比未照射的对照组高出三倍。在细胞毒性试验中，近红外照射的载药组的细胞活力约为17%，而近红外照射的空白组（无载药）的细胞活力仍高于80%。这些结果证实，纳米载体成功地将吉西他滨递送至靶细胞，并通过近红外刺激实现了药物的控释。
