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紧密连接蛋白处于炎症、屏障功能和疾病调节的交叉点。

Tight Junction Proteins at the Crossroads of Inflammation, Barrier Function, and Disease Modulation.

作者信息

Cha Hee-Jae

机构信息

Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Republic of Korea.

出版信息

Int J Mol Sci. 2025 Aug 22;26(17):8115. doi: 10.3390/ijms26178115.

DOI:10.3390/ijms26178115
PMID:40943041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12428315/
Abstract

Tight junctions (TJs), traditionally considered static structural elements sealing epithelial and endothelial monolayers, are now recognized as dynamic regulators of tissue homeostasis [...].

摘要

紧密连接（TJs），传统上被认为是封闭上皮和内皮单层的静态结构元件，现在被视为组织稳态的动态调节因子[...]。

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本文引用的文献

1
The intestinal barrier: a pivotal role in health, inflammation, and cancer.肠道屏障：在健康、炎症和癌症中起关键作用。
Lancet Gastroenterol Hepatol. 2025 Jun;10(6):573-592. doi: 10.1016/S2468-1253(24)00390-X. Epub 2025 Mar 11.
2
[Role of Mitochondria in Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease].[线粒体在炎症性肠病肠道上皮屏障功能障碍中的作用]
Mol Biol (Mosk). 2023 Nov-Dec;57(6):1028-1042.
3
Intestinal barrier functions in hematologic and oncologic diseases.血液系统和肿瘤疾病中的肠道屏障功能。
J Transl Med. 2023 Mar 31;21(1):233. doi: 10.1186/s12967-023-04091-w.
4
Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders.肠道屏障功能及其相关紊乱的氧化还原和代谢调节。
Int J Mol Sci. 2022 Nov 21;23(22):14463. doi: 10.3390/ijms232214463.
5
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.癌症与炎症中的紧密连接蛋白和信号通路：功能串扰
Front Physiol. 2019 Jan 23;9:1942. doi: 10.3389/fphys.2018.01942. eCollection 2018.
6
Tight junction proteins in gastrointestinal and liver disease.胃肠道和肝脏疾病中的紧密连接蛋白。
Gut. 2019 Mar;68(3):547-561. doi: 10.1136/gutjnl-2018-316906. Epub 2018 Oct 8.
7
Metabolic regulation of intestinal epithelial barrier during inflammation.炎症期间肠道上皮屏障的代谢调节
Tissue Barriers. 2015 Apr 3;3(1-2):e970936. doi: 10.4161/21688362.2014.970936. eCollection 2015.
8
Loss of tight junction barrier function and its role in cancer metastasis.紧密连接屏障功能丧失及其在癌症转移中的作用。
Biochim Biophys Acta. 2009 Apr;1788(4):872-91. doi: 10.1016/j.bbamem.2008.11.005. Epub 2008 Nov 14.
9
Tight junctions and the modulation of barrier function in disease.紧密连接与疾病中屏障功能的调节
Histochem Cell Biol. 2008 Jul;130(1):55-70. doi: 10.1007/s00418-008-0424-9. Epub 2008 Apr 16.