Branković Marija, Kraišnik Marija, Zdravković Dimitrije, Kraišnik Nemanja, Jelić Filip, Nikolić Novica, Đurašević Siniša, Tosti Tomislav, Gmizić Tijana, Todorović Zoran
University Hospital Medical Center Bežanijska kosa, 11000 Belgrade, Serbia.
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Int J Mol Sci. 2025 Aug 24;26(17):8214. doi: 10.3390/ijms26178214.
It is mostly known which microorganisms make up the intestinal microbiota and what their role is in the digestive tract. Moreover, there is evidence about the influence of these microorganisms, especially bacteria, on the functioning of the human body in general. Intestinal microbiota is metabolically active and synthesizes numerous molecules that are an important part of biochemical processes in the human body, as well as signaling pathways. Some of these molecules are of lipid origin, which is why new knowledge in the field of lipidomics can help in their more precise identification. It is now clear that the lipid profile of the stool depends on the composition and metabolic activity of the microbiota. Therefore, under changed conditions, such as the existence of an infection, there are changes in the lipid profile of the stool. One of the epidemiologically most important and most studied infections of the digestive tract is infection. This infection is recurrent in a large number of cases; it is related to resistance to antibiotics and their irrational use, and because of that, further research in this area would bring insight into possibly new knowledge that would help in more effective suppression of this infection.
人们大多已经知道构成肠道微生物群的是哪些微生物，以及它们在消化道中的作用是什么。此外，有证据表明这些微生物，尤其是细菌，总体上对人体功能有影响。肠道微生物群具有代谢活性，能合成众多分子，这些分子是人体生化过程以及信号通路的重要组成部分。其中一些分子源自脂质，这就是脂质组学领域的新知识有助于更精确鉴定它们的原因。现在很清楚，粪便的脂质谱取决于微生物群的组成和代谢活性。因此，在诸如感染存在等变化的条件下，粪便的脂质谱会发生变化。消化道在流行病学上最重要且研究最多的感染之一是[此处原文未明确感染名称]感染。这种感染在大量病例中会复发；它与对抗生素的耐药性及其不合理使用有关，正因为如此，该领域的进一步研究将带来可能有助于更有效抑制这种感染的新知识。
