可溶性α-klotho在脑衰老及其主要相关疾病中的抗炎作用

The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases.

作者信息

López-Valdés Héctor E, Hernández-Lucas Martín, Rodríguez-Fabián Gustavo D J, Esteban-Román Nadia F, Gutiérrez-Juárez Roger, Arrieta-Cruz Isabel, Martínez-Coria Hilda

机构信息

Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México City 04360, Mexico.

Departamento de Ciencias Biomédicas, Escuela de Medicina, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, México City 09230, Mexico.

出版信息

Int J Mol Sci. 2025 Sep 3;26(17):8551. doi: 10.3390/ijms26178551.

DOI:10.3390/ijms26178551

PMID:40943475

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12428826/

Abstract

The anti-aging protein α-Klotho has several therapeutic effects on different pathophysiological conditions, mainly its anti-inflammatory and antioxidant effects. Experimental evidence and observational studies suggest that there are several strategies to increase α-Klotho in the brain and enhance its beneficial effects, thus contributing to improving its neuroprotective and neuroplasticity mechanisms in brain aging, Alzheimer's, Parkinson's, and ischemic stroke diseases. In this article, we summarize the relevant information on α-Klotho, brain aging, Alzheimer's, Parkinson's, and ischemic stroke diseases and analyze the role of α-Klotho in each of these alterations, as well as the effect of physical exercise, exogenous application of α-klotho, and various drugs approved for different human diseases on α-Klotho production.

摘要

抗衰老蛋白α-klotho对不同的病理生理状况具有多种治疗作用，主要是其抗炎和抗氧化作用。实验证据和观察性研究表明，有几种策略可以增加大脑中的α-klotho并增强其有益作用，从而有助于改善其在脑衰老、阿尔茨海默病、帕金森病和缺血性中风疾病中的神经保护和神经可塑性机制。在本文中，我们总结了关于α-klotho、脑衰老、阿尔茨海默病、帕金森病和缺血性中风疾病的相关信息，并分析了α-klotho在这些改变中的作用，以及体育锻炼、α-klotho的外源性应用和针对不同人类疾病批准的各种药物对α-klotho产生的影响。