Cancer Center, Department of Ultrasound Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, China.
Department of Respiratory and Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, No. 127 West Changle Road, Xi'an, 710032, China.
BMC Endocr Disord. 2024 Sep 27;24(1):198. doi: 10.1186/s12902-024-01737-8.
Klotho plays a pivotal role in human aging. Metabolic syndrome (MetS) is composed of multiple conditions that are also risk factors for cardiovascular disease and diabetes. We try to discuss gender-specific differences in Klotho and the associations between Klotho and MetS components.
The National Health and Nutrition Examination Survey database from cycle 2015-2016 was analyzed. MetS was defined according to the 2005 updated criteria by the American Heart Association and National Heart Lung and Blood Institute. Gender-specific differences in serum Klotho, and associations between Klotho level and MetS components were examined.
A total of 2475 participants (40-79 years old) with comprehensive data were included (52% women). In general, lower Klotho was associated with advanced age, male sex, tobacco use, elevated triglycerides, renal insufficiency, inflammation, low estradiol, and low sex hormone-binding globulin (SHBG). The correlation between MetS and Klotho was more obvious in women, mainly in waist circumference and triglyceride. There were no gender-specific differences in the associations between Klotho and renal dysfunction, but multivariate linear regression analysis showed gender differences in other factors associated with Klotho. Estradiol, SHBG, high-density lipoprotein cholesterol (HDL), and high-sensitivity C-reactive protein (CRP) were associated with Klotho levels independent of age and renal function in men, whereas in women, Klotho was independently associated with triglycerides and white blood cell count.
Klotho levels had gender disparities regardless of age, renal function, and sex hormones. In the current cohort, triglycerides were the major component of MetS that was independently associated with serum Klotho levels, and the association was particularly seen in women. However, HDL was found to be the male-specific MetS component independently associated with Klotho.
Klotho 在人类衰老中起着关键作用。代谢综合征（MetS）由多种与心血管疾病和糖尿病风险因素相关的病症组成。我们试图讨论 Klotho 的性别特异性差异以及 Klotho 与 MetS 成分之间的关联。
分析了 2015-2016 年国家健康和营养检查调查数据库。MetS 根据美国心脏协会和国家心肺血液研究所 2005 年更新的标准定义。检查了血清 Klotho 中的性别特异性差异，以及 Klotho 水平与 MetS 成分之间的关联。
共有 2475 名（40-79 岁）具有综合数据的参与者被纳入（52%为女性）。一般来说，较低的 Klotho 与年龄增长、男性、吸烟、甘油三酯升高、肾功能不全、炎症、雌二醇降低和性激素结合球蛋白（SHBG）降低有关。MetS 与 Klotho 之间的相关性在女性中更为明显，主要与腰围和甘油三酯有关。在肾功能不全相关因素方面，Klotho 与性别之间没有差异，但多元线性回归分析显示，其他与 Klotho 相关的因素存在性别差异。在男性中，雌二醇、SHBG、高密度脂蛋白胆固醇（HDL）和高敏 C 反应蛋白（CRP）与 Klotho 水平相关，与年龄和肾功能无关，而在女性中，Klotho 与甘油三酯和白细胞计数独立相关。
无论年龄、肾功能和性激素如何，Klotho 水平都存在性别差异。在当前队列中，甘油三酯是与血清 Klotho 水平独立相关的 MetS 主要成分，这种关联在女性中尤为明显。然而，HDL 是与 Klotho 独立相关的男性特异性 MetS 成分。
