Chwil Mirosława, Dzida Katarzyna, Terlecka Paulina, Gruľová Daniela, Matraszek-Gawron Renata, Terlecki Karol, Kasprzyk Anna, Kostryco Mikołaj
Department of Botany and Plant Physiology, University of Life Sciences in Lublin, Akademicka 15 St., 20-950 Lublin, Poland.
Institute of Horticulture Production, Subdepartment of Plant Nutrition, University of Life Sciences in Lublin, Głęboka 28 St., 20-612 Lublin, Poland.
Int J Mol Sci. 2025 Sep 8;26(17):8737. doi: 10.3390/ijms26178737.
raw materials have long been used in Chinese folk medicine. The biologically active chemical compounds in , mainly lignans, e.g., honokiol, exert health-enhancing effects in certain diseases, including skin conditions. Since the scientific literature does not provide a comparative analysis of the therapeutic properties of honokiol on the skin in various biological models, an attempt was made to supplement the knowledge in this field. This review presents the antimicrobial, anti-inflammatory, and photoprotective properties of honokiol used in dermatological problems and its anticancer activity in melanoma and non-melanoma skin cancers. Honokiol reduces the expression of HSV-1 genes, inhibits DNA replication, lowers the level of proteins, regulates the colonisation of viral glycoproteins with high membrane selectivity, and inhibits the endocytosis process. It has antibacterial activity, as it destroys bacterial cell walls and membranes. It disrupts vacuolar functioning and intracellular calcium homeostasis in dermatophyte cells and inhibits fungal growth by delaying germination, altering membrane permeability, and reducing hyphal growth. It reduces inflammatory cytokines and stimulates anti-inflammatory cytokine IL-10. Honokiol prevents UV-B induced skin cancer through targeting cell cycle regulators, inflammatory mediators, and cell survival signals. It induces apoptosis via extrinsic and intrinsic pathways, activating proapoptotic proteins. It acts as an inhibitor of the oncogenic protein KRT18 in melanoma and prevents the progression of highly metastatic melanoma. Future research should explore the signalling pathways and molecular mechanisms of honokiol action and its synergistic effects at the cellular level and help to develop methods for delivering honokiol to the organism by nanocarriers to improve selective therapies in some diseases.
原材料长期以来一直应用于中国民间医学。[原材料名称]中的生物活性化合物，主要是木脂素，例如厚朴酚，在某些疾病（包括皮肤疾病）中发挥增强健康的作用。由于科学文献未对厚朴酚在各种生物学模型中对皮肤的治疗特性进行比较分析，因此尝试补充该领域的知识。本综述介绍了厚朴酚在皮肤病问题中的抗菌、抗炎和光保护特性及其在黑色素瘤和非黑色素瘤皮肤癌中的抗癌活性。厚朴酚可降低单纯疱疹病毒1型（HSV-1）基因的表达，抑制DNA复制，降低蛋白质水平，以高膜选择性调节病毒糖蛋白的定植，并抑制内吞过程。它具有抗菌活性，因为它会破坏细菌细胞壁和细胞膜。它会破坏皮肤癣菌细胞中的液泡功能和细胞内钙稳态，并通过延迟萌发、改变膜通透性和减少菌丝生长来抑制真菌生长。它可减少炎症细胞因子并刺激抗炎细胞因子IL-10。厚朴酚通过靶向细胞周期调节因子、炎症介质和细胞存活信号来预防紫外线B诱导的皮肤癌。它通过外源性和内源性途径诱导细胞凋亡，激活促凋亡蛋白。它在黑色素瘤中作为致癌蛋白KRT18的抑制剂，可防止高转移性黑色素瘤的进展。未来的研究应探索厚朴酚作用的信号通路和分子机制及其在细胞水平的协同效应，并有助于开发通过纳米载体将厚朴酚递送至机体的方法，以改善某些疾病的选择性治疗。
