斋月禁食对内皮功能、心血管危险因素和心血管疾病的影响。
The Impact of Ramadan Fasting on Endothelial Function, Cardiovascular Risk Factors, and Cardiovascular Disease.
作者信息
Ahmed Musaab, Ahmed Mohamed H, Shantakumari Nisha
机构信息
College of Medicine, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Department of Geriatric Medicine, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes MK6 5LD, UK.
出版信息
J Clin Med. 2025 Sep 2;14(17):6191. doi: 10.3390/jcm14176191.
Endothelial dysfunction, marked by reduced nitric oxide bioavailability, is a known factor in cardiovascular disorders. Prior studies have shown that dietary changes affect endothelial function and alter risk factors. Research studies have examined the possible impacts of Ramadan fasting on endothelial dysfunction. This narrative review aimed to assess the impacts of Ramadan fasting on endothelial function. We conducted a search of the PubMed and SCOPUS databases with various search terms. The review focused on research papers published in English language from 2000 to 2024. This review included sixty-six studies. Ramadan fasting elevated the levels and bioavailability of nitric oxide and improved some indicators of endothelial dysfunction. Ramadan fasting may enhance endothelial dysfunction and modify its risk factors, by promoting weight reduction and improving insulin resistance. Moreover, Ramadan fasting induced alterations in the structure, composition, abundance, and overexpression of gut microbiota. Further research is necessary to evaluate the safety, efficacy, and importance of Ramadan fasting on endothelial function and cardiovascular health.
内皮功能障碍以一氧化氮生物利用度降低为特征，是心血管疾病的一个已知因素。先前的研究表明，饮食变化会影响内皮功能并改变风险因素。研究已经探讨了斋月禁食对内皮功能障碍的可能影响。这篇叙述性综述旨在评估斋月禁食对内皮功能的影响。我们使用各种检索词在PubMed和SCOPUS数据库中进行了检索。该综述聚焦于2000年至2024年以英文发表的研究论文。这篇综述纳入了66项研究。斋月禁食提高了一氧化氮的水平和生物利用度，并改善了一些内皮功能障碍指标。斋月禁食可能通过促进体重减轻和改善胰岛素抵抗来增强内皮功能并改变其风险因素。此外，斋月禁食会引起肠道微生物群的结构、组成、丰度和过度表达的改变。有必要进行进一步研究以评估斋月禁食对内皮功能和心血管健康的安全性、有效性及重要性。
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