Gjerde H, Mørland J, Olsen H
J Steroid Biochem. 1985 Dec;23(6A):1091-2. doi: 10.1016/0022-4731(85)90074-3.
The effect of the glucocorticoid-antagonist RU486 (Roussel-Uclaf, France) on the increased activity of hepatic tryptophan oxygenase (TO) after administration of corticosterone and ethanol in rats was studied. RU486 (40 mg/kg per os) inhibited completely the effect of corticosterone (5-15 mg/kg injected intraperitoneally) on TO. Ethanol (4 g/kg) given intraperitoneally is followed by peak corticosterone concentrations comparable to those seen after the administration of 5-10 mg exogenous corticosterone, and increased the TO activity 3-fold 4 h after the injection. RU486 inhibited completely the ethanol-induced increase of TO, indicating that this increase is mediated by corticosterone.
研究了糖皮质激素拮抗剂RU486（法国罗素-优克福公司）对大鼠给予皮质酮和乙醇后肝色氨酸加氧酶（TO）活性增加的影响。RU486（40毫克/千克，经口给药）完全抑制了皮质酮（5 - 15毫克/千克，腹腔注射）对TO的作用。腹腔注射乙醇（4克/千克）后，皮质酮浓度峰值与给予5 - 10毫克外源性皮质酮后相当，并在注射后4小时使TO活性增加了3倍。RU486完全抑制了乙醇诱导的TO增加，表明这种增加是由皮质酮介导的。
