Pushpendra College of Pharmacy, Ambikapur, Surguja 497101, (C.G.), India.
Dr. C.V. Raman Institute of Pharmacy, Dr. C.V. Raman University, Bilaspur, C.G. 495113, India.
Mini Rev Med Chem. 2024;24(6):588-600. doi: 10.2174/0113895575262104230928042150.
Cortisol, commonly known as the "stress hormone," plays a critical role in the body's response to stress. Elevated cortisol levels have been associated with various mental disorders, including anxiety, depression, and post-traumatic stress disorder. Consequently, researchers have explored cortisol modulation as a promising avenue for treating these conditions. However, the availability of research on cortisol as a therapeutic option for mental disorders is limited, and existing studies employ diverse methodologies and outcome measures. This review article aimed to provide insights into different treatment approaches, both pharmacological and non-pharmacological, which can effectively modulate cortisol levels. Pharmacological interventions involve the use of substances, such as somatostatin analogs, dopamine agonists, corticotropin-releasing hormone antagonists, and cortisol synthesis inhibitors. Additionally, non-pharmacological techniques, including cognitivebehavioral therapy, herbs and supplements, transcranial magnetic stimulation, lifestyle changes, and surgery, have been investigated to reduce cortisol levels. The emerging evidence suggests that cortisol modulation could be a promising treatment option for mental disorders. However, more research is needed to fully understand the effectiveness and safety of these therapies.
皮质醇，通常被称为“应激激素”，在身体应对压力的反应中起着关键作用。皮质醇水平升高与各种精神障碍有关，包括焦虑、抑郁和创伤后应激障碍。因此，研究人员探索了皮质醇调节作为治疗这些疾病的有前途的方法。然而，关于皮质醇作为精神障碍治疗选择的研究可用性有限，并且现有研究采用了不同的方法和结果测量。这篇综述文章旨在深入了解不同的治疗方法，包括药理学和非药理学方法，这些方法可以有效地调节皮质醇水平。药理学干预包括使用物质，如生长抑素类似物、多巴胺激动剂、促肾上腺皮质激素释放激素拮抗剂和皮质醇合成抑制剂。此外，还研究了非药理学技术，包括认知行为疗法、草药和补充剂、经颅磁刺激、生活方式改变和手术，以降低皮质醇水平。新出现的证据表明，皮质醇调节可能是治疗精神障碍的一种有前途的治疗选择。然而，需要更多的研究来充分了解这些疗法的有效性和安全性。
