Wang D Y, Knyba R E
J Steroid Biochem. 1985 Dec;23(6A):975-9. doi: 10.1016/0022-4731(85)90055-x.
The daily amounts of salivary progesterone have been determined over the complete menstrual cycle for 9 normal women. The level of progesterone during the follicular phase was about 150 pmol/l and increased significantly to about 350 pmol/l during the luteal phase of the menstrual cycle. The amounts of salivary progesterone were significantly correlated with those in blood (P less than 0.001) in paired saliva-blood specimens taken from 96 women. Although these volunteers comprised patients with benign and malignant breast disease and normal unaffected women, the relationship between salivary and blood progesterone was similar for all groups. The concentration of non-protein-bound progesterone was determined using equilibrium dialysis. To correct for serum dilution the linear relationship between the percentage of progesterone bound and the reciprocal of serum dilution has been exploited. The values of non-protein-bound progesterone obtained were significantly and linearly correlated with levels in saliva (r = 0.75, P less than 0.001, d.f. = 34) although the amount of free progesterone in blood was about five times that found in saliva.
已测定9名正常女性整个月经周期的唾液孕酮日分泌量。卵泡期孕酮水平约为150皮摩尔/升，在月经周期的黄体期显著升高至约350皮摩尔/升。从96名女性采集的配对唾液-血液样本中，唾液孕酮含量与血液中的含量显著相关（P<0.001）。尽管这些志愿者包括患有良性和恶性乳腺疾病的患者以及未受影响的正常女性，但所有组中唾液孕酮与血液孕酮之间的关系相似。使用平衡透析法测定非蛋白结合孕酮的浓度。为校正血清稀释，利用了孕酮结合百分比与血清稀释倒数之间的线性关系。尽管血液中游离孕酮的量约为唾液中游离孕酮量的五倍，但所获得的非蛋白结合孕酮值与唾液中的水平显著线性相关（r = 0.75，P<0.001，自由度 = 34）。
